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Review
. 2015 Oct;37(10):1095-105.
doi: 10.1002/bies.201500065. Epub 2015 Sep 10.

SUMO-regulated transcription: challenging the dogma

Pierre Chymkowitch  1 , Aurélie Nguéa P  1 , Jorrit M Enserink  1
Affiliations
Review

SUMO-regulated transcription: challenging the dogma

Pierre Chymkowitch et al. Bioessays. 2015 Oct.

Abstract

The small ubiquitin-like modifier SUMO regulates many aspects of cellular physiology to maintain cell homeostasis, both under normal conditions and during cell stress. Components of the transcriptional apparatus and chromatin are among the most prominent SUMO substrates. The prevailing view is that SUMO serves to repress transcription. However, as we will discuss in this review, this model needs to be refined, because recent studies have revealed that SUMO can also have profound positive effects on transcription.

Keywords: RNA polymerase III; SUMO; UBLs; ribosomal proteins; stress response; tRNA; transcription.

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