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Comment
. 2015 Sep 9;18(3):268-9.
doi: 10.1016/j.chom.2015.08.013.

Bacteria in the CF Lung: Isolation Drives Diversity

Pablo Manfredi  1 , Urs Jenal  2
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Free article
Comment

Bacteria in the CF Lung: Isolation Drives Diversity

Pablo Manfredi et al. Cell Host Microbe. .
Free article

Abstract

In-host pathogen evolution influences disease progression and chronicity, but forces that shape this remain poorly understood. In this issue of Cell Host & Microbe, Jorth et al. (2015) describe regional subpopulations of Pseudomonas aeruginosa in lungs from cyctic fibrosis patients and provide support for compartmentalization-driven evolution of this bacterium.

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  • Regional Isolation Drives Bacterial Diversification within Cystic Fibrosis Lungs.
    Jorth P, Staudinger BJ, Wu X, Hisert KB, Hayden H, Garudathri J, Harding CL, Radey MC, Rezayat A, Bautista G, Berrington WR, Goddard AF, Zheng C, Angermeyer A, Brittnacher MJ, Kitzman J, Shendure J, Fligner CL, Mittler J, Aitken ML, Manoil C, Bruce JE, Yahr TL, Singh PK. Jorth P, et al. Cell Host Microbe. 2015 Sep 9;18(3):307-19. doi: 10.1016/j.chom.2015.07.006. Epub 2015 Aug 20. Cell Host Microbe. 2015. PMID: 26299432 Free PMC article.

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