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. 2015 Sep-Oct;16(5):1153-62.
doi: 10.3348/kjr.2015.16.5.1153. Epub 2015 Aug 21.

Relationship between Myocardial Extracellular Space Expansion Estimated with Post-Contrast T1 Mapping MRI and Left Ventricular Remodeling and Neurohormonal Activation in Patients with Dilated Cardiomyopathy

Ji Hyun Yoon  1 , Jung Woo Son  1 , Hyemoon Chung  1 , Chul Hwan Park  2 , Young-Jin Kim  1 , Hyuk-Jae Chang  2 , Geu-Ru Hong  1 , Tae Hoon Kim  2 , Jong-Won Ha  1 , Byoung Wook Choi  2 , Se-Joong Rim  1 , Namsik Chung  1 , Eui-Young Choi  1
Affiliations

Relationship between Myocardial Extracellular Space Expansion Estimated with Post-Contrast T1 Mapping MRI and Left Ventricular Remodeling and Neurohormonal Activation in Patients with Dilated Cardiomyopathy

Ji Hyun Yoon et al. Korean J Radiol. 2015 Sep-Oct.

Erratum in

Abstract

Objective: Post-contrast T1 values are closely related to the degree of myocardial extracellular space expansion. We determined the relationship between post-contrast T1 values and left ventricular (LV) diastolic function, LV remodeling, and neurohormonal activation in patients with dilated cardiomyopathy (DCM).

Materials and methods: Fifty-nine patients with DCM (mean age, 55 ± 15 years; 41 males and 18 females) who underwent both 1.5T magnetic resonance imaging and echocardiography were enrolled. The post-contrast 10-minute T1 value was generated from inversion time scout images obtained using the Look-Locker inversion recovery sequence and a curve-fitting algorithm. The T1 sample volume was obtained from three interventricular septal points, and the mean T1 value was used for analysis. The N-Terminal pro-B-type natriuretic peptide (NT-proBNP) level was measured in 40 patients.

Results: The mean LV ejection fraction was 24 ± 9% and the post-T1 value was 254.5 ± 46.4 ms. The post-contrast T1 value was significantly correlated with systolic longitudinal septal velocity (s'), peak late diastolic velocity of the mitral annulus (a'), the diastolic elastance index (Ed, [E/e']/stroke volume), LV mass/volume ratio, LV end-diastolic wall stress, and LV end-systolic wall stress. In a multivariate analysis without NT-proBNP, T1 values were independently correlated with Ed (β = -0.351, p = 0.016) and the LV mass/volume ratio (β = 0.495, p = 0.001). When NT-proBNP was used in the analysis, NT-proBNP was independently correlated with the T1 values (β = -0.339, p = 0.017).

Conclusion: Post-contrast T1 is closely related to LV remodeling, diastolic function, and neurohormonal activation in patients with DCM.

Keywords: Diastolic function; Dilated cardiomyopathy; T1 mapping.

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Figures

Fig. 1
Fig. 1. Representative case of measuring post-T1 value in Look-Locker-based inversion time scout images.
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