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. 2015 Sep 10;9(9):e0003896.
doi: 10.1371/journal.pntd.0003896. eCollection 2015 Sep.

Antivenoms for Snakebite Envenoming: What Is in the Research Pipeline?

Emilie Alirol  1 , Pauline Lechevalier  2 , Federica Zamatto  2 , François Chappuis  3 , Gabriel Alcoba  3 , Julien Potet  4
Affiliations

Antivenoms for Snakebite Envenoming: What Is in the Research Pipeline?

Emilie Alirol et al. PLoS Negl Trop Dis. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram of the selection process used in this study.
The search was conducted on 15 September 2014. Merging the search results gave a total of 41 clinical trials investigating the efficacy or safety of snake antivenoms, of which four were active. A total of 36 different antivenoms were investigated (see Table 2). Based on the trial design (Phase I to IV), ten products were considered still “under development,” although development appears to have stalled for most of them. Our search strategy appears robust; a report conducted in 2010 identified a total of 43 randomized controlled trials on snakebite envenoming, 28 of which investigated antivenom properties [11]. We retrieved all except two of these trials [12,51]; the discrepancy could be due to differences in the criteria used to define clinical trials.
See this image and copyright information in PMC

References

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