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Review
. 2015 Jun 28;3(2):99-108.
doi: 10.14218/JCTH.2015.00007. Epub 2015 Jun 15.

Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment Options

Tawfik Khoury  1 , Ayman Abu Rmeileh  1 , Liron Yosha  1 , Ariel A Benson  2 , Saleh Daher  2 , Meir Mizrahi  3
Affiliations
Review

Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment Options

Tawfik Khoury et al. J Clin Transl Hepatol. .

Abstract

Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug reaction. DILI may mimic any morphologic characteristic of acute or chronic liver disease, and the histopathologic features of DILI may be indistinguishable from those of other causes of liver injury, such as acute viral hepatitis. In this review article, we provide an update on causative agents, clinical features, pathogenesis, diagnosis modalities, and outcomes of DILI. In addition, we review results of recently reported genetic studies and updates on pharmacological and invasive treatments.

Keywords: DILI; Hepatotoxicity; Treatment.

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Conflict of interest statement

Conflict of interest: None

Figures

Fig. 1
Fig. 1. Algorithm for drug induced liver injury (DILI) diagnosis.
ALT, alanine aminotransferase; ALP, alkaline phosphatase; CMV, cytomegalovirus; EBV, Epstein-Barr virus; HCV, hepatitis C virus; HBV, hepatitis B virus, HEV, hepatitis E virus, HSV, herpes simplex virus; MRCP, magnetic resonance cholangiopancreatography; EUS, endoscopic ultrasound; TIBC, total iron binding capacity; HIV, human immunedeficiency virus.
See this image and copyright information in PMC

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