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. 2015 Aug;15(3):e338-43.
doi: 10.18295/squmj.2015.15.03.006. Epub 2015 Aug 24.

Gallium-67 Scintigraphy in the Era of Positron Emission Tomography and Computed Tomography: Tertiary centre experience

Badriya Al-Suqri  1 , Naima Al-Bulushi  1
Affiliations

Gallium-67 Scintigraphy in the Era of Positron Emission Tomography and Computed Tomography: Tertiary centre experience

Badriya Al-Suqri et al. Sultan Qaboos Univ Med J. 2015 Aug.

Abstract

Objectives: Although (18)F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) has largely replaced the use of gallium-67 ((67)Ga) scintigraphy in the evaluation and follow-up of lymphoma patients, (67)Ga scans are still of value, particularly in countries where no PET/CT service is available. The current study presents the experience of a tertiary care centre using (67)Ga scintigraphy for the evaluation of lymphomas and infections.

Methods: A retrospective review was conducted of all (67)Ga scans performed between 2007 and 2011 at the Royal Hospital in Muscat, Oman. Images and reports of (67)Ga scans were compared to clinical and radiological follow-up data including CT and PET/CT scans and biopsies when available.

Results: A total of 74 patients were referred for (67)Ga scintigraphy during this period with 12 patients excluded due to lack of follow-up data, resulting in 62 patients. Among these patients, 90 (67)Ga scans were performed, including 59 for lymphoma, 29 for infection and two for sarcoidosis assessment. Of the infection assessment scans, 22 were performed to assess pyrexia of unknown origin and seven for follow-up after known infections. Sensitivity and specificity were found to be 80% and 88%, respectively, for the lymphoma assessment scans. For the infection assessment scans, sensitivity and specificity were reported to be 80% and 100%, respectively.

Conclusion: Results from this study were consistent with other reported rates of (67)Ga scan sensitivity and specificity in the evaluation of lymphomas and infections. This indicates that (67)Ga scintigraphy is a useful tool for these types of evaluations when PET/CT services are not available.

Keywords: Fever of Unknown Origin; Fluorodeoxyglucose F18; Gallium Radioisotopes; Gallium-67-Citrate; Infection; Lymphoma; Oman; Scintigraphy.

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Figures

Figure 1:
Figure 1:
Gallium-67 scintigraphy images revealing pericardial uptake (arrows) in a patient with pyrexia of unknown origin. Echocardiography and aspiration revealed tuberculosis (TB) pericarditis. The patient was subsequently treated with anti-TB medication. RT = right; LT = left.
Figure 2:
Figure 2:
Gallium-67 scintigraphy images showing left suprarenal uptake (arrows) in a child with pyrexia of unknown origin. Computed tomography and a subsequent biopsy revealed a neuroblastoma. RT = right; LT = left.
Figure 3:
Figure 3:
Gallium-67 scintigraphy images showing mediastinal (red arrow) and thymic uptake (blue arrow) in a patient referred for lymphoma assessment. A biopsy revealed Hodgkin’s lymphoma. RT = right; LT = left.
See this image and copyright information in PMC

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