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Comment
. 2015 Oct 14;34(20):2489-91.
doi: 10.15252/embj.201592859. Epub 2015 Sep 10.

Stomaching Notch

Xiaolei Yin  1 , Jeffrey M Karp  2
Affiliations
Comment

Stomaching Notch

Xiaolei Yin et al. EMBO J. .

Abstract

The self-renewal and differentiation of tissue stem cells must be tightly controlled. Unrestrained self-renewal leads to over-proliferation of stem cells, which may cause tumor formation, while uncontrolled differentiation leads to depletion of the stem cell pool. In this issue of The EMBO Journal, Demitrack et al (2015) show that the Notch pathway is a key regulator of Lgr5 antral stem cell self-renewal and differentiation. Notch signaling controls the proliferation and differentiation of stem cells as well as gastric tissue growth, while uncontrolled Notch activity in stem cells leads to polyp formation.

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Figures

Figure 1
Figure 1. Notch pathway regulates Lgr5 stem cell self-renewal and differentiation
(A) The Notch signaling pathway. (B, C) Notch regulates the self-renewal and the differentiation of Lgr5 stem cells in (B) the small intestine and (C) the stomach as shown in Demitrack et al (2015).
See this image and copyright information in PMC

Comment on

  • Notch signaling regulates gastric antral LGR5 stem cell function.
    Demitrack ES, Gifford GB, Keeley TM, Carulli AJ, VanDussen KL, Thomas D, Giordano TJ, Liu Z, Kopan R, Samuelson LC. Demitrack ES, et al. EMBO J. 2015 Oct 14;34(20):2522-36. doi: 10.15252/embj.201490583. Epub 2015 Aug 12. EMBO J. 2015. PMID: 26271103 Free PMC article.

References

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