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Editorial
. 2015 Dec;17(12):1543-4.
doi: 10.1093/neuonc/nov188. Epub 2015 Sep 10.

How neuronal activity regulates glioma cell proliferation

Affiliations
Editorial

How neuronal activity regulates glioma cell proliferation

Mariella G Filbin et al. Neuro Oncol. 2015 Dec.
No abstract available

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Figures

Fig. 1.
Fig. 1.
Model demonstrating that neuronal activity induces neuroligin-3 secretion, leading to subsequent glioma cell proliferation through activation of PI3K/mTOR signaling.

Comment on

  • Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.
    Venkatesh HS, Johung TB, Caretti V, Noll A, Tang Y, Nagaraja S, Gibson EM, Mount CW, Polepalli J, Mitra SS, Woo PJ, Malenka RC, Vogel H, Bredel M, Mallick P, Monje M. Venkatesh HS, et al. Cell. 2015 May 7;161(4):803-16. doi: 10.1016/j.cell.2015.04.012. Epub 2015 Apr 23. Cell. 2015. PMID: 25913192 Free PMC article.

References

    1. Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012;21(3):309–322. - PubMed
    1. Venkatesh HS, Johung TB, Caretti V, et al. Neuronal activity promotes glioma growth through neuroligin-3 secretion. Cell. 2015;161(4):803–816. - PMC - PubMed
    1. Gibson EM, Purger D, Mount CW, et al. Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science. 2014;344(6183):1252304. - PMC - PubMed
    1. Monje M, Mitra SS, Freret ME, et al. Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci U S A. 2011;108(11):4453–4458. - PMC - PubMed
    1. Wang Y, Yang J, Zheng H, et al. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell. 2009;15(6):514–526. - PMC - PubMed

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