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. 2015 Sep 10;162(6):1186-90.
doi: 10.1016/j.cell.2015.08.038.

Releasing the Brakes on Cancer Immunotherapy

Dan R Littman  1
Affiliations
Free article

Releasing the Brakes on Cancer Immunotherapy

Dan R Littman. Cell. .
Free article

Abstract

This year's Lasker∼DeBakey Clinical Research Award goes to James Allison for discovering that antibody blockade of the T cell molecule CTLA-4 unleashes the body's immune response against malignant tumors. This has led to development of multiple "immune checkpoint therapies" that are prolonging and saving the lives of thousands of cancer patients.

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