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. 2015 Nov:119:90-5.
doi: 10.1016/j.phytochem.2015.09.001. Epub 2015 Sep 8.

Jubanines F-J, cyclopeptide alkaloids from the roots of Ziziphus jujuba

Kyo Bin Kang  1 , Gao Ming  2 , Geum Jin Kim  2 , Thi-Kim-Quy Ha  1 , Hyukjae Choi  2 , Won Keun Oh  1 , Sang Hyun Sung  3
Affiliations

Jubanines F-J, cyclopeptide alkaloids from the roots of Ziziphus jujuba

Kyo Bin Kang et al. Phytochemistry. 2015 Nov.

Abstract

Five Ib-type cyclopeptide alkaloids, jubanines F-J (1-5), and three known compounds, nummularine B (6), daechuine-S3 (7), and mucronine K (8) were isolated from the roots of Ziziphus jujuba. Their structures were fully characterized by spectroscopic analyses in combination with chemical derivatization. Compounds 1-3, and 6 were evaluated for their antiviral activity against the porcine epidemic diarrhea virus (PEDV). Compounds 2, 3, and 6 showed potent inhibitory effects on PEDV replication.

Keywords: Antiviral; Cyclopeptide alkaloids; Jubanines; Rhamnaceae; Ziziphus jujuba.

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Figures

None
Graphical abstract
Fig. 1
Fig. 1
Chemical structures of compounds 1–8.
Fig. 2
Fig. 2
Selected COSY, HMBC, and NOESY interactions for compound 1.
See this image and copyright information in PMC

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