Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Sep 11:16:22.
doi: 10.1186/s40360-015-0024-y.

Does antihypertensive treatment with renin-angiotensin system inhibitors prevent the development of diabetic kidney disease?

Hiroki Miyazaki  1   2 , Akira Babazono  3 , Takumi Nishi  4 , Toshiki Maeda  5 , Takuya Imatoh  6 , Masayoshi Ichiba  7 , Hiroshi Une  8
Affiliations

Does antihypertensive treatment with renin-angiotensin system inhibitors prevent the development of diabetic kidney disease?

Hiroki Miyazaki et al. BMC Pharmacol Toxicol. .

Abstract

Background: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide. Renin-angiotensin system (RAS) inhibitors are the first-line treatment for diabetic patients with hypertension. However, whether RAS inhibitors prevent the development of DKD remains controversial. We conducted a retrospective cohort study quantifying the preventive effect of antihypertensive treatment with RAS inhibitors on DKD, using data from specific health check-ups and health insurance claims.

Methods: The study subjects were 418 patients with diabetes and hypertension, drawn from health insurance societies located in Fukuoka and Shizuoka prefectures in Japan. The subjects were divided into three groups, according to the type of antihypertensive treatment they received. They were then compared in terms of the development of DKD, using the diagnostic codes from ICD-10.

Results: Thirty subjects (6.2%) developed DKD during the study period between April 2011 and September 2013. RAS inhibitor treated group showed a significantly lower risk of DKD [adjusted odds ratio (AOR) = 0.35; 95% confidential interval (CI): 0.16-0.76] compared with the no treatment group.

Conclusion: We conclude that antihypertensive treatment with RAS inhibitors is potentially useful for preventing the development of DKD.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Inclusion and exclusion flowchart. DM; diabetes mellitus, CHD; coronary heart disease, CKD; chronic kidney disease
See this image and copyright information in PMC

References

    1. de Boer IH, Rue TC, Hall YN, Heagerty PJ, Weiss NS, Himmelfarb J. Temporal trends in the prevalence of diabetic kidney disease in the United States. JAMA. 2011;305(24):2532–9. doi: 10.1001/jama.2011.861. - DOI - PMC - PubMed
    1. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351(13):1296–305. doi: 10.1056/NEJMoa041031. - DOI - PubMed
    1. National Kidney F. KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update. Am J Kidney Dis. 2012;60(5):850–86. doi: 10.1053/j.ajkd.2012.07.005. - DOI - PubMed
    1. Afkarian M, Sachs MC, Kestenbaum B, Hirsch IB, Tuttle KR, Himmelfarb J, de Boer IH. Kidney disease and increased mortality risk in type 2 diabetes. J Am Soc Nephrol. 2013;24(2):302–8. doi: 10.1681/ASN.2012070718. - DOI - PMC - PubMed
    1. Fioretto P, Bruseghin M, Berto I, Gallina P, Manzato E, Mussap M. Renal protection in diabetes: role of glycemic control. J Am Soc Nephrol. 2006;17(4 Suppl 2):S86–9. doi: 10.1681/ASN.2005121343. - DOI - PubMed

Publication types

MeSH terms

Substances