Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Oct;15(10):83.
doi: 10.1007/s11892-015-0648-8.

Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits

Tugce Karaderi  1 , Alexander W Drong  2 , Cecilia M Lindgren  3   4   5
Affiliations
Review

Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits

Tugce Karaderi et al. Curr Diab Rep. 2015 Oct.

Abstract

Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.

Keywords: Adiponectin; Beta-cell function; Body mass index; Fat distribution; Fat percent; Genome-wide association study; Insulin resistance; Leptin; Non-alcoholic fatty liver disease; Obesity; Pericardial fat; Sexual dimorphism; Subcutaneous fat; Type 2 diabetes; Visceral fat; Waist-to-hip ratio.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Genome-wide hits for T2D and obesity-related traits loci. GWAS data were obtained from GWAS catalog (http://www.ebi.ac.uk/gwas/, accessed 26 June 2015). Search terms used included obesity, type 2 diabetes, adiposity, waist, fat, body mass index, non-alcoholic liver, adiponectin, weight and adipose. P value threshold for association was p < 5 × 10−8. Associations are labeled with corresponding trait colors
Fig. 2
Fig. 2
Risk at T2D autosomal loci [••] vs. BMI [••]. P value thresholds for association with BMI (y-axis) are p < 5 × 10−8 (red), 5 × 10−8 ≤ p < 10−4 (orange), 10−4 ≤ p < 0.01 (yellow), 0.01 ≤ p < 0.05 (green) and p ≥ 0.05 (blue). Red, orange and yellow associations are labeled with corresponding gene names
Fig. 3
Fig. 3
Risk at T2D autosomal loci [••] vs. WHRadjBMI [••]. P value thresholds for association with WHRadjBMI (y-axis) are p < 5 × 10−8 (red), 5 × 10−8 ≤ p < 10−4 (orange), 10−4 ≤ p < 0.01 (yellow), 0.01 ≤ p < 0.05 (green) and p ≥ 0.05 (blue). Red, orange and yellow associations are labeled with corresponding gene names
See this image and copyright information in PMC

References

    1. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444(7121):840–6. doi: 10.1038/nature05482. - DOI - PubMed
    1. Tsigos C, Hainer V, Basdevant A, et al. Management of obesity in adults: European clinical practice guidelines. Obes Facts. 2008;1(2):106–16. doi: 10.1159/000126822. - DOI - PMC - PubMed
    1. Kilpelainen TO, Zillikens MC, Stancakova A, et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet. 2011;43(8):753–60. doi: 10.1038/ng.866. - DOI - PMC - PubMed
    1. Fox CS, Liu Y, White CC, et al. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. PLoS Genet. 2012;8(5):e1002695. doi: 10.1371/journal.pgen.1002695. - DOI - PMC - PubMed
    1. Fox CS, Massaro JM, Hoffmann U, et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007;116(1):39–48. doi: 10.1161/CIRCULATIONAHA.106.675355. - DOI - PubMed

Publication types

LinkOut - more resources