Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Dec;40(6):689-92.
doi: 10.1111/jcpt.12322. Epub 2015 Sep 14.

Febuxostat-associated drug reaction with eosinophilia and systemic symptoms (DRESS)

H-Y Chou  1 , C-B Chen  2   3 , C-Y Cheng  1 , Y-A Chen  4 , C Y Ng  3   5 , K-L Kuo  2   3 , W-L Chen  1 , C-H Chen  1
Affiliations
Case Reports

Febuxostat-associated drug reaction with eosinophilia and systemic symptoms (DRESS)

H-Y Chou et al. J Clin Pharm Ther. 2015 Dec.

Abstract

What is known and objective: Febuxostat is recommended as an alternative drug for gouty patients with a history of allopurinol hypersensitivity or carrying the HLA-B*5801 allele.

Case summary: An 81-year-old man with the medical history of gout presented to our clinic with generalized rashes for 2 days. After taking febuxostat for 2 days, he developed generalized skin rash with high fever. Laboratory tests showed elevated liver enzymes and acute kidney injury.

What is known and objective: This is the first identified case of febuxostat-associated DRESS. Febuxostat should be withdrawn immediately when DRESS is observed to avoid further serious complications.

Keywords: Febuxostat; adverse drug reaction; drug reaction with eosinophilia and systemic symptoms.

PubMed Disclaimer

Publication types