Facial primer provides immediate and long-term improvements in mild-to-moderate facial hyperpigmentation and fine lines associated with photoaging

Abstract

Background: Photoaged skin results from various environmental factors, most importantly chronic sun exposure. Dyschromia and fine lines/wrinkles are common clinical manifestations of photodamaged skin.

Purpose: This single-center clinical trial was conducted to assess the efficacy and tolerability of a new multifunctional facial primer (camouflage, broad-spectrum SPF 50, and a treatment for hyperpigmentation) when used by females with mild-to-moderate facial hyperpigmentation and fine lines due to photoaging over a course of 12 weeks.

Patients and methods: Subjects were provided test material (Even Up-Clinical Pigment Perfector) and supporting products to use on their face and neck. Products were used according to specific application instructions. Clinical grading for efficacy and tolerability assessments were performed by an expert grader at baseline, baseline (post-application primer), week 4, week 8, week 12, and week 12 (post-application primer). Standardized digital photographs were taken, and self-assessment questionnaires were conducted.

Results: Twenty-eight female subjects completed the 12-week trial. The facial primer improved scores for the appearance of hyperpigmentation and other photoaging parameters immediately after the first application. The treatment also showed a progressive improvement in the clinical assessment of hyperpigmentation and other photoaging parameters over the 12-week trial. These long-term benefits can be attributed to an improvement in the underlying skin condition. The facial primer was well tolerated. Subject questionnaires showed that the product was highly rated at all visits.

Conclusion: The facial primer was shown to be effective and well tolerated for immediate and long-term improvement in the appearance of mild-to-moderate hyperpigmentation and fine lines associated with photodamage when used over a 12-week period.

Keywords: SPF; cosmetic; dermocosmetic; medical makeup; photodamaged facial skin.

Figure 1

Facial primer provides immediate improvement in the hyperpigmentation score at first application of primer with greater improvement at week 12 compared to baseline. Note: *P≤0.001.

Figure 2

Facial primer provides significant improvement in additional parameters of photodamage at first application with greater improvement at week 12 compared to baseline. Note: All P≤0.001.

Figure 3

Significant progressive improvements in the hyperpigmentation score with use of the facial primer over 12 weeks (no facial primer applied for these assessments). Note: All P≤0.001.

Figure 4

Photographs of a 55-year-old subject with Fitzpatrick skin type II: baseline (left photo) and after 12 weeks of test product (without primer applied [center photo] and with primer applied [right photo]).

Figure 5

Photographs of a 49-year-old subject with Fitzpatrick skin type III: baseline (left photo) and after 12 weeks of test product (without primer applied [center photo] and with primer applied [right photo]).

Figure 6

Photographs of a 62-year-old subject with Fitzpatrick skin type IV: baseline (left photo) and after 12 weeks of test product (without primer applied [center photo] and with primer applied [right photo]).