Model-based analysis on the influence of spatial frequency selection in spatial frequency domain imaging

Abstract

Frequency variation in spatial frequency domain imaging is a powerful tool for adjusting the penetration depth of the imaging signal and the parameter sensitivity toward absorption and diffusive and subdiffusive scattering. Through our computational analysis, using an analytical solution of the radiative transfer equation, we add quantitation to this tool by linking the different spatial frequency regimes to their relative information content and to their absolute depth sensitivity. Special focus is placed on high spatial frequencies by analysis of the phase function parameter γ and its significance and ambiguity in describing subdiffusive scattering.