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Comment
. 2015 Sep 16;13(9):e1002252.
doi: 10.1371/journal.pbio.1002252. eCollection 2015 Sep.

Cellular Defense Enzyme Drives Exceptionally High Rate of Mutation in HIV

Richard Robinson  1
Affiliations
Comment

Cellular Defense Enzyme Drives Exceptionally High Rate of Mutation in HIV

Richard Robinson. PLoS Biol. .

Abstract

HIV-1 is already known to have an extremely fast mutation rate, but a new study shows it to be more than two orders of magnitude higher than previously believed, and that this is largely due to host cytidine deaminases. Read the Research Article.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. HIV-1 infected cell.
The image shows a microphotography of an infected cell obtained with a scanning electron microscope. The cellular surface and budding viruses have been colored. Image credit: NIAID, Flickr.
See this image and copyright information in PMC

Comment on

  • Extremely High Mutation Rate of HIV-1 In Vivo.
    Cuevas JM, Geller R, Garijo R, López-Aldeguer J, Sanjuán R. Cuevas JM, et al. PLoS Biol. 2015 Sep 16;13(9):e1002251. doi: 10.1371/journal.pbio.1002251. eCollection 2015. PLoS Biol. 2015. PMID: 26375597 Free PMC article.

References

    1. Cuevas JM, Geller R, Garijo R, Lopez-Aldeguer J, Sanjuan R. Extremely High Mutation Rate of HIV-1 In Vivo. PLOS Biol. 2015;13(9): e1002251 doi: 10.1371/journal.pbio.1002251 - DOI - PMC - PubMed

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