. 2016 Mar 1;138(5):1129-38.

doi: 10.1002/ijc.29853. Epub 2015 Oct 1.

Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk: A nested case-control study in nonsmoking postmenopausal women from the EPIC cohort

Mireia Obón-Santacana¹, Heinz Freisling², Petra H Peeters^{3

4}, Leila Lujan-Barroso¹, Pietro Ferrari², Marie-Christine Boutron-Ruault^{5

6

7}, Sylvie Mesrine^{5

6

7}, Laura Baglietto^{8

9}, Renee Turzanski-Fortner¹⁰, Verena A Katzke¹⁰, Heiner Boeing¹¹, J Ramón Quirós¹², Elena Molina-Portillo^{13

14}, Nerea Larrañaga^{14

15}, María-Dolores Chirlaque^{14

16

17}, Aurelio Barricarte^{14

18

19}, Kay-Tee Khaw²⁰, Nick Wareham²¹, Ruth C Travis²¹, Melissa A Merritt⁴, Marc J Gunter⁴, Antonia Trichopoulou²², Pagona Lagiou^{22

23}, Androniki Naska^{22

23}, Domenico Palli²⁴, Sabina Sieri²⁵, Rosario Tumino²⁶, Valentina Fiano²⁷, Rocco Galassom²⁸, H B As Bueno-de-Mesquita^{4

29

30

31}, N Charlotte Onland-Moret³², Annika Idahl^{33

34}, Eva Lundin³⁵, Elisabete Weiderpass^{36

37

38

39}, Hubert Vesper⁴⁰, Elio Riboli⁴, Eric J Duell¹

Affiliations

¹ Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
² Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France.
³ Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
⁵ Inserm, CESP Centre for Research in Epidemiology and Population Health, Lifestyle, Genes and Health: Integrative Trans-Generational Epidemiology, Villejuif, France.
⁶ Universite Paris Sud, Villejuif, France.
⁷ Institut Gustave-Roussy (IGR), Villejuif, France.
⁸ Cancer Council of Victoria, Cancer Epidemiology Centre, Melbourne, Australia.
⁹ Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.
¹⁰ Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹¹ Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany.
¹² Public Health Directorate, Asturias, Spain.
¹³ Escuela Andaluza De Salud Pública, Instituto De Investigación Biosanitaria Ibs, GRANADA, Hospitales Universitarios De Granada/Universidad De Granada, Granada, Spain.
¹⁴ CIBER, Epidemiology and Public Health CIBERESP, Madrid, Spain.
¹⁵ Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Gipuzkoa, Spain.
¹⁶ Department of Epidemiology, Regional Health Council, Murcia, Spain.
¹⁷ Department of Health and Social Sciences, Murcia University, Murcia, Spain.
¹⁸ Navarra Public Health Institute, Pamplona, Spain.
¹⁹ Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
²⁰ University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
²¹ Nuffield Department of Population Health University of Oxford, Cancer Epidemiology Unit, Oxford, United Kingdom.
²² Hellenic Health Foundation, Athens, Greece.
²³ Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
²⁴ Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy.
²⁵ Epidemiology and Prevention Unit, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
²⁶ Cancer Registry and Histopathology Unit, "Civic - M.P.Arezzo" Hospital, ASP Ragusa, Italy.
²⁷ Department of Medical Sciences University of Turin, Unit of Cancer Epidemiology-CERMS, Turin, Italy.
²⁸ Biostatistics and Cancer Registry, IRCCS Centro Di Riferimento Oncologico Di Basilicata, Unit of Clinical Epidemiology, Rionero in Vulture, Potenza, Italy.
²⁹ Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
³⁰ Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands.
³¹ Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
³² Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
³³ Department of Clinical Sciences, Obstetrics and Gynecology, Nutritional Research Umeå University, Umeå, Sweden.
³⁴ Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, Umeå, Sweden.
³⁵ Department of Medical Biosciences, Pathology Umeå University, Umeå, Sweden.
³⁶ Department of Community Medicine, Faculty of Health Sciences, the Arctic University of Norway, University of Tromsø, Tromsø, Norway.
³⁷ Department of Research, Cancer Registry of Norway, Oslo, Norway.
³⁸ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
³⁹ Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.
⁴⁰ Centers for Disease Control and Prevention, Atlanta, GA.

PMID: 26376083
PMCID: PMC4716289
DOI: 10.1002/ijc.29853

Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk: A nested case-control study in nonsmoking postmenopausal women from the EPIC cohort

Mireia Obón-Santacana et al. Int J Cancer. 2016.

. 2016 Mar 1;138(5):1129-38.

doi: 10.1002/ijc.29853. Epub 2015 Oct 1.

Authors

Affiliations

¹ Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
² Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France.
³ Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
⁵ Inserm, CESP Centre for Research in Epidemiology and Population Health, Lifestyle, Genes and Health: Integrative Trans-Generational Epidemiology, Villejuif, France.
⁶ Universite Paris Sud, Villejuif, France.
⁷ Institut Gustave-Roussy (IGR), Villejuif, France.
⁸ Cancer Council of Victoria, Cancer Epidemiology Centre, Melbourne, Australia.
⁹ Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.
¹⁰ Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹¹ Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany.
¹² Public Health Directorate, Asturias, Spain.
¹³ Escuela Andaluza De Salud Pública, Instituto De Investigación Biosanitaria Ibs, GRANADA, Hospitales Universitarios De Granada/Universidad De Granada, Granada, Spain.
¹⁴ CIBER, Epidemiology and Public Health CIBERESP, Madrid, Spain.
¹⁵ Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Gipuzkoa, Spain.
¹⁶ Department of Epidemiology, Regional Health Council, Murcia, Spain.
¹⁷ Department of Health and Social Sciences, Murcia University, Murcia, Spain.
¹⁸ Navarra Public Health Institute, Pamplona, Spain.
¹⁹ Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
²⁰ University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
²¹ Nuffield Department of Population Health University of Oxford, Cancer Epidemiology Unit, Oxford, United Kingdom.
²² Hellenic Health Foundation, Athens, Greece.
²³ Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
²⁴ Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy.
²⁵ Epidemiology and Prevention Unit, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
²⁶ Cancer Registry and Histopathology Unit, "Civic - M.P.Arezzo" Hospital, ASP Ragusa, Italy.
²⁷ Department of Medical Sciences University of Turin, Unit of Cancer Epidemiology-CERMS, Turin, Italy.
²⁸ Biostatistics and Cancer Registry, IRCCS Centro Di Riferimento Oncologico Di Basilicata, Unit of Clinical Epidemiology, Rionero in Vulture, Potenza, Italy.
²⁹ Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
³⁰ Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands.
³¹ Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
³² Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
³³ Department of Clinical Sciences, Obstetrics and Gynecology, Nutritional Research Umeå University, Umeå, Sweden.
³⁴ Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, Umeå, Sweden.
³⁵ Department of Medical Biosciences, Pathology Umeå University, Umeå, Sweden.
³⁶ Department of Community Medicine, Faculty of Health Sciences, the Arctic University of Norway, University of Tromsø, Tromsø, Norway.
³⁷ Department of Research, Cancer Registry of Norway, Oslo, Norway.
³⁸ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
³⁹ Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.
⁴⁰ Centers for Disease Control and Prevention, Atlanta, GA.

PMID: 26376083
PMCID: PMC4716289
DOI: 10.1002/ijc.29853

Abstract

Acrylamide, classified in 1994 by IARC as "probably carcinogenic to humans," was discovered in 2002 in some heat-treated, carbohydrate-rich foods. Four prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The purpose of this nested case-control study, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, was to evaluate, for the first time, the association between hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA) and the risk of developing EC in non-smoking postmenopausal women. Hemoglobin adducts were measured in red blood cells by HPLC/MS/MS. Four exposure variables were evaluated: HbAA, HbGA, their sum (HbAA+HbGA), and their ratio (HbGA/HbAA). The association between hemoglobin adducts and EC was evaluated using unconditional multivariable logistic regression models, and included 383 EC cases (171 were type-I EC), and 385 controls. Exposure variables were analyzed in quintiles based on control distributions. None of the biomarker variables had an effect on overall EC (HRHbAA;Q5vsQ1 : 0.84, 95%CI: 0.49-1.48; HRHbGA;Q5vsQ1 : 0.94, 95%CI: 0.54-1.63) or type-I EC risk. Additionally, none of the subgroups investigated (BMI < 25 vs. ≥25 kg m(-2) , alcohol drinkers vs. never drinkers, oral contraceptive users vs. non-users) demonstrated effect measure modification. Hemoglobin adducts of acrylamide or glycidamide were not associated with EC or type-I EC risk in 768 nonsmoking postmenopausal women from the EPIC cohort.

Keywords: EPIC; acrylamide; endometrial cancer; glycidamide; hemoglobin adduct.

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Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk: A nested case-control study in nonsmoking postmenopausal women from the EPIC cohort

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Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk: A nested case-control study in nonsmoking postmenopausal women from the EPIC cohort

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