Implications of the discovery of brain lymphatic pathways

Affiliations

¹ Department of Anesthesiology and Perioperative Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.
² Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA; Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark.
³ Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA; Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark. Electronic address: nedergaard@urmc.rochester.edu.

Comment

Jeffrey J Iliff et al. Lancet Neurol. 2015 Oct.

. 2015 Oct;14(10):977-9.

doi: 10.1016/S1474-4422(15)00221-5.

¹ Department of Anesthesiology and Perioperative Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.
² Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA; Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark.
³ Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA; Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark. Electronic address: nedergaard@urmc.rochester.edu.

No abstract available

Comment on

Structural and functional features of central nervous system lymphatic vessels.
Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J. Louveau A, et al. Nature. 2015 Jul 16;523(7560):337-41. doi: 10.1038/nature14432. Epub 2015 Jun 1. Nature. 2015. PMID: 26030524 Free PMC article.
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.
Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K. Aspelund A, et al. J Exp Med. 2015 Jun 29;212(7):991-9. doi: 10.1084/jem.20142290. Epub 2015 Jun 15. J Exp Med. 2015. PMID: 26077718 Free PMC article.

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