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. 2015 Sep 17:10:167.
doi: 10.1186/s13000-015-0401-2.

Overexpression of Trps1 contributes to tumor angiogenesis and poor prognosis of human osteosarcoma

Zhishuang Li  1 , Ming Jia  2 , Xiaojuan Wu  3 , Jingjing Cui  4 , Aifeng Pan  5 , Li Li  6
Affiliations

Overexpression of Trps1 contributes to tumor angiogenesis and poor prognosis of human osteosarcoma

Zhishuang Li et al. Diagn Pathol. .

Abstract

Background: Trichorhinophalangeal syndrome 1 (Trps1) gene is a member of GATA transcription factor family and has an important function in tumorigenesis and progression. However, there are rare studies on its roles in carcinogenesis and prognostic significance in human osteosarcoma.

Methods: The expression of Trps1 was detected by immunohistochemistry, and MVD was evaluated to determine the amounts of microvessels by counting CD31-positive endothelial cells.

Results: Of the 74 cases that underwent study, Trps1-positive cases were 24. And it was associated with MVD significantly (P = 0.008). The data also exhibited more cases of remote metastasis (P = 0.013) and higher Enneking stage (P = 0.017) in Trps1-positive group compared to Trps1-negative group. Univariate analysis revealed that distant metastasis, MVD and Trps1 expression were associated with a lower 3-year overall survival rate and disease-free survival rate (P = 0.003, and P = 0.012 respectively). Furthermore, Trps1 and distant metastasis retained their significant prognostic effects on patients survival rate by multivariate analysis (P < 0.05).

Conclusions: Trps1 plays a crucial role in osteosarcoma angiogenesis, metastasis and clinical surgical stage. Trps1 can be a novel promising prognostic marker and therapeutic target, and antiangiogenic therapy which targets Trps1 molecule in patients with osteosarcoma may lead to improved prognosis and longer-term survival.

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Figures

Fig. 1
Fig. 1
Trichorhinophalangeal syndrome type 1 (Trps1) and CD31 expression in osteosarcoma tissues by Immunohistochemical staining. CD31 indicates intratumoural microvessels. Representative Fields showed the negative outcome of Trps1 and CD31 (upper row, ×200) and the positive outcome (lower row, ×200). Trps1-positive staining was observed in nucleus. The cut-off value of microvessels was 41/×200 field
Fig. 2
Fig. 2
Different Kaplan-Meier curves of overall and disease-free survival curves stratified in terms of the differential expression of Trps1. Figure 2a showed that there was a significant difference in 3-year DFS rate between Trps1-positive and Trps1-negative (41.7 % vs 66 %, P = 0.012). Figure 2b showed a worse 3-year OS rate in Trps1-positive group (41.7 % vs 70.0 %, P = 0.003)
See this image and copyright information in PMC

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