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Comment
. 2015 Sep 15;43(3):409-11.
doi: 10.1016/j.immuni.2015.08.027.

Stressed-Out Endoplasmic Reticulum Inflames the Mitochondria

Sunny Shin  1 , Yair Argon  2
Affiliations
Free article
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Stressed-Out Endoplasmic Reticulum Inflames the Mitochondria

Sunny Shin et al. Immunity. .
Free article

Abstract

Bacterial infection induces inflammasome activation and release of interleukin-1 (IL-1) cytokines. Bronner et al. (2015) show that during Brucella abortus infection, an endoplasmic reticulum stress sensor, IRE1α, initiates NLRP3- and caspase-2-mediated mitochondrial damage that potentiates NLRP3 inflammasome assembly.

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