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Comment
. 2015 Sep 29;112(39):11989-90.
doi: 10.1073/pnas.1514689112. Epub 2015 Sep 16.

Assembly of the unusual oxacycles in the orthosomycin antibiotics

Amie K Boal  1 , J Martin Bollinger Jr  2 , Wei-chen Chang  3
Affiliations
Comment

Assembly of the unusual oxacycles in the orthosomycin antibiotics

Amie K Boal et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Oxacycles in orthosomycins (A) and possible mechanisms for their formation (B).
Fig. 2.
Fig. 2.
Comparison of HygX (putative oxacyclization enzyme) (Left, PDB ID code 4XCB) and SyrB2 halogenase (Right, PDB ID code 2FCT) structures showing a conserved ligand deletion pattern (Top).
See this image and copyright information in PMC

Comment on

References

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    1. McCulloch KM, et al. Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily. Proc Natl Acad Sci USA. 2015;112(37):11547–11552. - PMC - PubMed
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