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. 2015 Nov 3;113(9):1381-8.
doi: 10.1038/bjc.2015.333. Epub 2015 Sep 17.

Impact of alcohol drinking on gastric cancer development according to Helicobacter pylori infection status

Seung-Hyun Ma  1   2 , Woohyun Jung  3 , Elisabete Weiderpass  4   5   6   7 , Jieun Jang  1   8 , Yunji Hwang  1   2   8 , Chunghyun Ahn  1   8 , Kwang-Pil Ko  9 , Soung-Hoon Chang  10 , Hai-Rim Shin  11 , Keun-Young Yoo  1 , Sue K Park  1   2   8
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Impact of alcohol drinking on gastric cancer development according to Helicobacter pylori infection status

Seung-Hyun Ma et al. Br J Cancer. .

Abstract

Background: Helicobacter pylori are major carcinogen of gastric cancer, but the associations among gastric cancer, H. pylori infection status, and alcohol consumption are not fully described. This study aimed to clarify how H. pylori infection status affects the association between alcohol consumption and gastric cancer risk.

Methods: We selected 949 case-cohort participants from the 18,863 Korean Multi-center Cancer Cohort (KMCC) populations. Gastric cancer incidence inside and outside of the subcohort were 12 and 254 cases, respectively. Seropositivities for CagA, VacA, and H. pylori infection were determined by performing immunoblot assays. Weighted Cox regression models were used to calculate hazard ratios and 95% confidence intervals (CIs).

Results: Relative to non-drinking, heavy drinking (⩾7 times a week), and binge drinking (⩾55 g alcohol intake per occasion) showed a 3.48-fold (95% CI, 1.13-10.73) and 3.27-fold (95% CI, 1.01-10.56) higher risk in subjects not previously infected by H. pylori. There was no significant association between drinking pattern and gastric cancer risk in H. pylori IgG seropositive subjects. An increased risk for gastric cancer in heavy- and binge-drinking subjects were also present in subjects not infected by CagA- or VacA-secreting H. pylori.

Conclusions: Heavy and binge alcohol consumption is an important risk factor related to an increasing incidence of gastric cancer in a population not infected by H. pylori.

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Figures

Figure 1
Figure 1
HRs (solid line) and 95% CIs for baseline alcohol consumption and gastric cancer risk assessed by using restricted cubic spline regression in KMCC cohort. The spline regression model excluded extreme consumption (top 1%, ⩾200 g per day; three cases). Weighted model (four knots) adjusted for age (1-year categories), sex, BMI, and smoking status.
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