Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Sep 1;5(11):1249-63.
doi: 10.7150/thno.11544. eCollection 2015.

Magnetic Nanoparticles in Cancer Theranostics

Oliviero L Gobbo  1 , Kristine Sjaastad  2 , Marek W Radomski  3 , Yuri Volkov  4 , Adriele Prina-Mello  4
Affiliations
Review

Magnetic Nanoparticles in Cancer Theranostics

Oliviero L Gobbo et al. Theranostics. .

Abstract

In a report from 2008, The International Agency for Research on Cancer predicted a tripled cancer incidence from 1975, projecting a possible 13-17 million cancer deaths worldwide by 2030. While new treatments are evolving and reaching approval for different cancer types, the main prevention of cancer mortality is through early diagnosis, detection and treatment of malignant cell growth. The last decades have seen a development of new imaging techniques now in widespread clinical use. The development of nano-imaging through fluorescent imaging and magnetic resonance imaging (MRI) has the potential to detect and diagnose cancer at an earlier stage than with current imaging methods. The characteristic properties of nanoparticles result in their theranostic potential allowing for simultaneous detection of and treatment of the disease. This review provides state of the art of the nanotechnological applications for cancer therapy. Furthermore, it advances a novel concept of personalized nanomedical theranostic therapy using iron oxide magnetic nanoparticles in conjunction with MRI imaging. Regulatory and industrial perspectives are also included to outline future perspectives in nanotechnological cancer research.

Keywords: Cancer; Drug delivery; Magnetic nanoparticles; Theranostic Nanomedicine; Thermal therapy.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Schematic of a multilayered SPION with personalized medicine application. The figure depicts the three main components formed by “layering” an iron oxide nanoparticle: (1) engineered Nano-Particle (ENP) core, (2) biocompatible coating and (3) therapeutic coating/targeting ligand. Reproduced with permission from Handbook of Clinical Nanomedicine: Nanoparticles, Imaging, Therapy and Clinical Applications (Movia D, Poland C, Tran L, Volkov Y, Prina-Mello A. Multilayered Nanoparticles for Personalized Medicine: Translation into Clinical Markets). Copyright Pan Stanford Publishing Pte. Ltd.
Figure 2
Figure 2
Overview of in vivo magnetofection.
Figure 3
Figure 3
In vivo magnetic hyperthermia treatment in mouse. MNPs could be injected intravenously or directly into the tumour of a mouse and an applied alternating current magnetic field increases temperature in the tumour tissue. The temperature reached in the tumour centre depends on the nanoparticle concentration.
Figure 4
Figure 4
Example of magnetic nanoparticle for theranostic applications (http://www.multifun-project.eu/). Reproduced with permission from Drs. Terán and Somoza (IMDEA-Nanociencia, Madrid, Spain).
See this image and copyright information in PMC

References

    1. Feynman RP. http://calteches.library.caltech.edu/1976/1/1960Bottom.pdf.
    1. Fu A, Gu W, Larabell C, Alivisatos AP. Semiconductor nanocrystals for biological imaging. Current opinion in neurobiology. 2005;15:568–75. doi:10.1016/j.conb.2005.08.004. - PubMed
    1. Bruchez M, Moronne M, Gin P, Weiss S, Alivisatos AP. Semiconductor Nanocrystals as Fluorescent Biological Labels. Science. 1998;281:2013–6. doi:10.1126/science.281.5385.2013. - PubMed
    1. Corot C, Robert P, Idee JM, Port M. Recent advances in iron oxide nanocrystal technology for medical imaging. Adv Drug Deliv Rev. 2006;58:1471–504. doi:10.1016/j.addr.2006.09.013. - PubMed
    1. Stoll G, Bendszus M. Imaging of inflammation in the peripheral and central nervous system by magnetic resonance imaging. Neuroscience. 2009;158:1151–60. doi:10.1016/j.neuroscience.2008.06.045. - PubMed

Publication types

MeSH terms

LinkOut - more resources