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Review
. 2015 Jul 15;8(7):10340-57.
eCollection 2015.

Biomarkers of head and neck cancer, tools or a gordian knot?

Evangeli S Lampri  1 , Georgios Chondrogiannis  2 , Elli Ioachim  3 , Anna Varouktsi  4 , Antigoni Mitselou  5 , Aggeliki Galani  6 , Evangelos Briassoulis  7 , Panagiotis Kanavaros  2 , Vasiliki Galani  2
Affiliations
Review

Biomarkers of head and neck cancer, tools or a gordian knot?

Evangeli S Lampri et al. Int J Clin Exp Med. .

Abstract

Head and neck tumors comprise a wide spectrum of heterogeneous neoplasms for which biomarkers are needed to aid in earlier diagnosis, risk assessment and therapy response. Personalized medicine based on predictive markers linked to drug response, it is hoped, will lead to improvements in outcomes and avoidance of unnecessary treatment in carcinoma of the head and neck. Because of the heterogeneity of head and neck tumors, the integration of multiple selected markers in association with the histopathologic features is advocated for risk assessment. Validation of each biomarker in the context of clinical trials will be required before a specific marker can be incorporated into daily practice. Furthermore, we will give evidence that some proteins implicated in cell-cell interaction, such as CD44 may be involved in the multiple mechanism of the development and progression of laryngeal lesions and may help to predict the risk of transformation of the benign or precancerous lesions to cancer.

Keywords: HPV; carcinogenesis; genetic; molecular; pharyngeal carcinoma; squamous cell carcinoma.

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References

    1. Williams MD. Integration of biomarkers including molecular targeted therapies in head and neck cancer. Head Neck Pathol. 2010;4:62–69. - PMC - PubMed
    1. Jemal A, Siegel R, Xu J. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277–300. - PubMed
    1. Ward BB. Biomarkers for Head and Neck Cancer. SPOMS. Volume 13. 3:1–48.
    1. Diaz EM, Sturges EM, Laramore GE, Sabichi AL, Clayman G. Neoplasms of the Head and Neck. In: Kufe DW, Pollock RE, Weichselbaum RR, editors. Cancer medicine. Vol. 2. Hamilton (Ontario, Canada): American Cancer Society BC Dekker Inc.; 2003. pp. 1325–72.
    1. Crowe DL, Hacia JG, Hsieh CL, Sinha UK, Rice H. Molecular pathology of head and neck cancer. Histol Histopathol. 2002;17:909–14. - PubMed

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