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Review
. 2015 Aug 25;4(F1000 Faculty Rev):626.
doi: 10.12688/f1000research.6288.1. eCollection 2015.

Sevoflurane

Stefan De Hert  1 , Anneliese Moerman  1
Affiliations
Review

Sevoflurane

Stefan De Hert et al. F1000Res. .

Abstract

Sevoflurane has been available for clinical practice for about 20 years. Nowadays, its pharmacodynamic and pharmacokinetic properties together with its absence of major adverse side effects on the different organ systems have made this drug accepted worldwide as a safe and reliable anesthetic agent for clinical practice in various settings.

Keywords: Sevoflurane; anesthesiology; anesthetic; pharmacodynamic; pharmacokinetic.

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Conflict of interest statement

Competing interests: Stefan De Hert has received speakers fees from Abbott and AbbVie. Anneliese Moerman declares that she has no competing interests.

References

    1. Wallin RF, Regan BM, Napoli MD, et al. : Sevoflurane: a new inhalational anesthetic agent. Anesth Analg. 1975;54(6):758–66. 10.1213/00000539-197511000-00021 - DOI - PubMed
    1. Hitt B, Mazze R, Cook T, et al. : Thermoregulatory defect in rats during anesthesia. Anesth Analg. 1977;56(1):9–15. 10.1213/00000539-197701000-00006 - DOI - PubMed
    1. Patel SS, Goa KL: Sevoflurane. A review of its pharmacodynamic and pharmacokinetic properties and its clinical use in general anaesthesia. Drugs. 1996;51(4):658–700. 10.2165/00003495-199651040-00009 - DOI - PubMed
    1. Strum DP, Eger EI 2nd: Partition coefficients for sevoflurane in human blood, saline, and olive oil. Anesth Analg. 1987;66(7):654–6. 10.1213/00000539-198707000-00013 - DOI - PubMed
    1. Scheller MS, Saidman LJ, Partridge BL: MAC of sevoflurane in humans and the New Zealand white rabbit. Can J Anaesth. 1988;35(2):153–6. 10.1007/BF03010656 - DOI - PubMed

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