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. 2015:2015:147973.
doi: 10.1155/2015/147973. Epub 2015 Aug 26.

Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis

Lidia Decembrino  1 , Mara De Amici  2 , Margherita Pozzi  1 , Annalisa De Silvestri  3 , Mauro Stronati  1
Affiliations

Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis

Lidia Decembrino et al. J Immunol Res. 2015.

Abstract

Introduction: The correct diagnosis of neonatal sepsis is a relevant problem because sepsis is one of the most important causes of neonatal morbidity, mortality, and prolonged hospital stay. Calprotectin is an antimicrobial, calcium and zinc binding heterocomplex protein that could be used as a nonspecific marker for activation of granulocytes and mononuclear phagocytes. Calprotectin has been proposed for the diagnosis of inflammatory conditions. Our aim is to study serum calprotectin as a biomarker for neonatal sepsis diagnosis.

Methods: 41 (20 females, 21 males) infants who underwent blood culture due to suspected sepsis were enrolled in the study. Serum calprotectin was measured by a commercial ELISA assay (Calprest, Eurospital, Trieste, Italy). Statistical analysis was performed using the statistical software package Stata 13.1 (Stata Corporation, College Station, Texas, USA).

Results: 8 neonates (19.51%) showed sepsis with positive culture and 33 (80.49%) showed suspected sepsis. The optimal cut-off for calprotectin is 2.2 μg/mL with a sensitivity of 62.5% and a specificity of 69.7%.

Conclusions: Calprotectin may be considered a promising early, sensitive, specific marker of sepsis thanks to the importance of calprotectin in defense mechanisms and physiological functions of the immune system.

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Figures

Figure 1
Figure 1
Calprotectin: ROC curve.
See this image and copyright information in PMC

References

    1. Gerdes J. S. Diagnosis and management of bacterial infections in the neonate. Pediatric Clinics of North America. 2004;51(4):939–959. doi: 10.1016/j.pcl.2004.03.009. - DOI - PubMed
    1. Bizzarro M. J., Raskind C., Baltimore R. S., Gallagher P. G. Seventy-five years of neonatal sepsis at Yale: 1928–2003. Pediatrics. 2005;116(3):595–602. doi: 10.1542/peds.2005-0552. - DOI - PubMed
    1. Klouwenberg P. K., Bont L. Neonatal and infantile immune responses to encapsulated bacteria and conjugate vaccines. Clinical and Developmental Immunology. 2008;2008:10. doi: 10.1155/2008/628963.628963 - DOI - PMC - PubMed
    1. Ng P. C. Diagnostic markers of infection in neonates. Archives of Disease in Childhood. 2004;89(3):F229–F235. doi: 10.1136/adc.2002.023838. - DOI - PMC - PubMed
    1. Fagerhol M. K., Dale I., Andersson T. Release and quantitation of a leucocyte derived protein (L1) Scandinavian Journal of Haematology. 1980;24(5):393–398.

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