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Comment
. 2015 Sep 17;525(7569):E1-2.
doi: 10.1038/nature14851.

Decompensated cirrhosis and microbiome interpretation

Jasmohan S Bajaj  1 , Naga S Betrapally  2 , Patrick M Gillevet  2
Affiliations
Comment

Decompensated cirrhosis and microbiome interpretation

Jasmohan S Bajaj et al. Nature. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing Financial Interests Declared none.

Figures

Figure 1
Figure 1. Microbiota distribution between compensated and decompensated cirrhotic subjects
a, LFSe plot showing metagenomic species that are overexpressed (green) and under-expressed (red) in decompensated compared to compensated cirrhosis from Qin et al.. b, In the new data set using MTPS, boxplots showing interquartile range of median abundance of statistically significant comparisons between controls (orange), compensated cirrhosis (green) and decompensated cirrhosis (blue) using multiple corrections-adjusted Kruskal–Wallis tests at the family level. The line in the centre shows median.
See this image and copyright information in PMC

Comment in

  • Qin et al. reply.
    Qin N, Le Chatelier E, Guo J, Prifti E, Li L, Ehrlich SD. Qin N, et al. Nature. 2015 Sep 17;525(7569):E2-3. doi: 10.1038/nature14852. Nature. 2015. PMID: 26381989 No abstract available.

Comment on

  • Alterations of the human gut microbiome in liver cirrhosis.
    Qin N, Yang F, Li A, Prifti E, Chen Y, Shao L, Guo J, Le Chatelier E, Yao J, Wu L, Zhou J, Ni S, Liu L, Pons N, Batto JM, Kennedy SP, Leonard P, Yuan C, Ding W, Chen Y, Hu X, Zheng B, Qian G, Xu W, Ehrlich SD, Zheng S, Li L. Qin N, et al. Nature. 2014 Sep 4;513(7516):59-64. doi: 10.1038/nature13568. Epub 2014 Jul 23. Nature. 2014. PMID: 25079328

References

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    1. Bajaj JS, et al. Linkage of gut microbiome with cognition in hepatic encephalopathy. Am J Physiol Gastrointest Liver Physiol. 2012;302:G168–G175. - PMC - PubMed
    1. Chen Y, et al. Characterization of fecal microbial communities in patients with liver cirrhosis. Hepatology. 2011;54:562–572. - PubMed
    1. Bajaj JS, et al. Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation. Am J Physiol Gastrointest Liver Physiol. 2012;303:G675–G685. - PMC - PubMed