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Review
. 2015 Oct;16(10):1014-24.
doi: 10.1038/ni.3273.

Autophagy and autophagy-related proteins in the immune system

Shusaku T Shibutani  1   2 , Tatsuya Saitoh  3 , Heike Nowag  4 , Christian Münz  4 , Tamotsu Yoshimori  1   2
Affiliations
Review

Autophagy and autophagy-related proteins in the immune system

Shusaku T Shibutani et al. Nat Immunol. 2015 Oct.

Abstract

Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond autophagy. In this Review, we introduce advances in the knowledge of the roles of autophagy and its components in immunity, including innate immunity, inflammatory responses and adaptive immunity.

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References

    1. Cell Host Microbe. 2008 Nov 13;4(5):458-69 - PubMed
    1. Cancer Res. 2008 Sep 1;68(17):6889-95 - PubMed
    1. Mol Cell. 2014 Jul 17;55(2):238-52 - PubMed
    1. Mol Biol Cell. 2008 Nov;19(11):4762-75 - PubMed
    1. Nature. 2013 Mar 21;495 (7441):389-93 - PubMed

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