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Comment
. 2015 Sep 17;59(6):883-4.
doi: 10.1016/j.molcel.2015.09.003.

SPOP Mutations or ERG Rearrangements Result in Enhanced Levels of ERG to Promote Cell Invasion in Prostate Cancer

Shanshan Duan  1 , Michele Pagano  2
Affiliations
Comment

SPOP Mutations or ERG Rearrangements Result in Enhanced Levels of ERG to Promote Cell Invasion in Prostate Cancer

Shanshan Duan et al. Mol Cell. .

Abstract

In this issue, An et al. (2015) and Gan et al. (2015) reveal that the CRL3(SPOP) ubiquitin ligase mediates the degradation of the transcription factor ERG and that translocations of ERG or mutations in SPOP prevent CRL3(SPOP)-dependent degradation of ERG in prostate cancer cells.

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Figures

Figure 1
Figure 1. Schematic Representation of the CRL3SPOP Ubiquitin Ligase Complex
Some of the best-established identified substrates of SPOP and the diverse effects they exert on cells are also shown.
See this image and copyright information in PMC

Comment on

References

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