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. 2009:22:378-386.

fMRI-Based Inter-Subject Cortical Alignment Using Functional Connectivity

Bryan R Conroy  1 , Benjamin D Singer  2 , James V Haxby  3 , Peter J Ramadge  1
Affiliations

fMRI-Based Inter-Subject Cortical Alignment Using Functional Connectivity

Bryan R Conroy et al. Adv Neural Inf Process Syst. 2009.

Abstract

The inter-subject alignment of functional MRI (fMRI) data is important for improving the statistical power of fMRI group analyses. In contrast to existing anatomically-based methods, we propose a novel multi-subject algorithm that derives a functional correspondence by aligning spatial patterns of functional connectivity across a set of subjects. We test our method on fMRI data collected during a movie viewing experiment. By cross-validating the results of our algorithm, we show that the correspondence successfully generalizes to a secondary movie dataset not used to derive the alignment.

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Figures

Figure 1
Figure 1
The registration algorithms.
Figure 2
Figure 2
Consistency Histograms. (a) Intra-subject warp distances; (b) Inter-subject warp distances; (c) Angle between warp vectors across sessions; (d) Across-session normalized warp consistency measure WNC.
Figure 3
Figure 3
Map of ISC on right cortical hemisphere, alignment: anatomical (top), functional (bottom).
See this image and copyright information in PMC

References

    1. Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain. Thieme Publishing Group; 1988.
    1. Fischl B, Tootell RBH, Dale AM. High-resolution intersubject averaging and a coordinate system for the cortical surface. Human Brain Mapping. 1999;8:272–284. - PMC - PubMed
    1. Watson JDG, Myers R, Frackowiak RSF, Hajnal JV, Woods RP, Mazziotta JC, Shipp S, Zeki S. Area v5 of the human brain: evidence from a combined study using positron emission tomography and magnetic resonance imaging. Cerebral Cortex. 1993;3:79–94. - PubMed
    1. Rademacher J, Caviness VS, Steinmetz H, Galaburda AM. Topographical variation of the human primary cortices: implications for neuroimaging, brain mapping and neurobiology. Cerebral Cortex. 1995;3:313–329. - PubMed
    1. Sabuncu MR, Singer BD, Conroy B, Bryan RE, Ramadge PJ, Haxby JV. Function-based inter-subject alignment of human cortical anatomy. [Access published on May 6, 2009];Cerebral Cortex Advance. doi: 10.1093/cercor/bhp085. - DOI

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