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Comparative Study
. 2015 Sep 9:9:5195-201.
doi: 10.2147/DDDT.S89669. eCollection 2015.

Pentoxifylline and electromagnetic field improved bone fracture healing in rats

Yusuf Atalay  1 , Nedim Gunes  2 , Mehmet Dervis Guner  3 , Veysi Akpolat  4 , Mustafa Salih Celik  4 , Rezzan Guner  2
Affiliations
Comparative Study

Pentoxifylline and electromagnetic field improved bone fracture healing in rats

Yusuf Atalay et al. Drug Des Devel Ther. .

Abstract

Background: The aim of this study was to evaluate the effects of a phosphodiesterase inhibitor pentoxifylline (PTX), electromagnetic fields (EMFs), and a mixture of both materials on bone fracture healing in a rat model.

Materials and methods: Eighty male Wistar rats were randomly divided into four groups: Group A, femur fracture model with no treatment; Group B, femur fracture model treated with PTX 50 mg/kg/day intraperitoneal injection; Group C, femur fracture model treated with EMF 1.5±0.2 Mt/50 Hz/6 hours/day; and Group D, femur fracture model treated with PTX 50 mg/kg/day intraperitoneal injection and EMF 1.5±0.2 Mt/50 Hz/6 hours/day.

Results: Bone fracture healing was significantly better in Group B and Group C compared to Group A (P<0.05), but Group D did not show better bone fracture healing than Group A (P>0.05).

Conclusion: It can be concluded that both a specific EMF and PTX had a positive effect on bone fracture healing but when used in combination, may not be beneficial.

Keywords: bones; electromagnetic fields; fracture healing; pentoxifylline; phosphodiesterase inhibitor; rats.

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Figures

Figure 1
Figure 1
A photographic image of the surgical procedure showing the gap between the bone segments after fixing the microplate.
Figure 2
Figure 2
Comparison of histopathological bone-healing scores among groups according to the Huo scale. Notes: *Contradictory values; – median value of control 21 group. Abbreviations: EMF, electromagnetic field; PTX, pentoxifylline; MIX, both EMF and PTX treatment.
Figure 3
Figure 3
Histopathological sample of bone tissue. The sample shows mostly cartilage and a little newly formed, immature bone tissue. Notes: The sample is stained with hematoxylin and eosin; magnification, 200×.
Figure 4
Figure 4
Histopathological sample of bone tissue. The sample shows mostly immature bone tissue. Notes: The sample is stained with hematoxylin and eosin; magnification, 200×.
Figure 5
Figure 5
Histopathological sample of bone tissue. The sample is mostly mature bone tissue. Notes: The sample is stained with hematoxylin and eosin; magnification, 200×.
See this image and copyright information in PMC

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