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. 2015 Oct;33(10):1076-8.
doi: 10.1038/nbt.3358. Epub 2015 Sep 21.

Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering

Dieter Blancquaert  1 , Jeroen Van Daele  2 , Simon Strobbe  1 , Filip Kiekens  2 , Sergei Storozhenko  1 , Hans De Steur  3 , Xavier Gellynck  3 , Willy Lambert  2 , Christophe Stove  2 , Dominique Van Der Straeten  1
Affiliations

Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering

Dieter Blancquaert et al. Nat Biotechnol. 2015 Oct.

Abstract

Biofortification of staple crops could help to alleviate micronutrient deficiencies in humans. We show that folates in stored rice grains are unstable, which reduces the potential benefits of folate biofortification. We obtain folate concentrations that are up to 150 fold higher than those of wild-type rice by complexing folate to folate-binding proteins to improve folate stability, thereby enabling long-term storage of biofortified high-folate rice grains.

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