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. 2015 Sep 14;12(9):11528-48.
doi: 10.3390/ijerph120911528.

Serum Adiponectin and Leptin Concentrations in Relation to Body Fat Distribution, Hematological Indices and Lipid Profile in Humans

Anna Lubkowska  1 , Aleksandra Radecka  2 , Iwona Bryczkowska  3 , Iwona Rotter  4 , Maria Laszczyńska  5 , Wioleta Dudzińska  6
Affiliations

Serum Adiponectin and Leptin Concentrations in Relation to Body Fat Distribution, Hematological Indices and Lipid Profile in Humans

Anna Lubkowska et al. Int J Environ Res Public Health. .

Abstract

The purpose of the study was to evaluate the relationship between serum adiponectin and leptin concentrations and body composition, hematological indices and lipid profile parameters in adults. The study involved 95 volunteers (BMI from 23.3 to 53 kg/m²). Anthropometric parameters were measured: body weight and height, waist and hip circumference, waist-to-hip ratio, body fat mass (BMF), subcutaneous and visceral fat mass (SFM, VFM), lean body mass (LBM), skeletal muscle mass (SMM). In serum we determined adiponectin and leptin concentrations, extracellular hemoglobin, total bilirubin, as well as lipid metabolism (TCh, HDL-Ch, LDL-Ch, TG). Mean adipokine levels were significantly higher in women (p ≤ 0.01), adiponectin significantly negatively correlated with body height and weight, systolic blood pressure and absolute LBM and SMM values. The same relation was observed for erythroid system indicators and lipid indicators. A positive correlation was exceptionally found between adiponectin and HDL-Ch. LEP negatively correlated with some percentage rates (%LBM, %SMM). Only in women, we observed a positive correlation between LEP and body weight, BMI and WHR. Studies on ADPN and the ADPN/LEP ratio as a valuable complementary diagnostic element in the prediction and prevention of cardiovascular diseases need to be continued.

Keywords: ADPN/LEP ratio; adiponectin; body mass components; leptin; lipid profile.

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Figures

Figure 1
Figure 1
Scatter plots for the correlation (p < 0.05) between adiponectin and selected erythroid indicators in the study group.
Figure 2
Figure 2
Scatter plots for the correlation (p < 0.05) between adiponectin and selected blood lipid profile indicators.
Figure 3
Figure 3
Scatter plots for the correlation (p < 0.05) between leptin and selected red and white blood cell indicators in the entire study group.
Figure 4
Figure 4
Scatter plots for the correlation (p < 0.05) between leptin, adiponectin and the ADPN/LEP ratio and platelet counts and the TG:TCh ratio in the group of women.
See this image and copyright information in PMC

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