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Observational Study
. 2016 Apr;18(4):315-21.
doi: 10.1111/jch.12668. Epub 2015 Sep 22.

High Salt Intake Is Independently Associated With Hypertensive Target Organ Damage

Yuki Imaizumi  1 , Kazuo Eguchi  1 , Takeshi Murakami  2 , Kimika Arakawa  3 , Takuya Tsuchihashi  4 , Kazuomi Kario  1
Affiliations
Observational Study

High Salt Intake Is Independently Associated With Hypertensive Target Organ Damage

Yuki Imaizumi et al. J Clin Hypertens (Greenwich). 2016 Apr.

Abstract

The authors tested the hypothesis that high salt intake is associated with hypertensive target organ damage (TOD) independent of blood pressure (BP), and oxidative stress is a modifying factor of this association. A total of 369 community-dwelling Japanese adults (mean age, 67.5 years; 56.6% women) were examined in this observational study. At the patients' annual health check-ups, urinary salt excretion (U-SALT), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and albumin-creatinine ratio (UACR) were measured from first morning urine. U-SALT (β=0.14, P=.016) and 8-OHdG (β=0.13, P=.018) were both independently associated with logUACR. U-SALT was associated with TOD independent of BP level, and oxidative stress may be a modifying factor in the association between high salt intake and TOD. The elevation of 8-OHdG may be involved in the pathophysiology of TOD induced by salt intake.

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Figures

Figure 1
Figure 1
Association between urinary salt excretion (U‐SALT) and the urinary albumin‐to‐creatinine ratio (UACR) in all patients (N=369). U‐SALT was significantly correlated with log UACR (r=0.21, P<.01).
See this image and copyright information in PMC

References

    1. Mozaffarian D, Fahimi S, Singh GM, et al. Global sodium consumption and death from cardiovascular causes. N Engl J Med. 2014;371:624–634. - PubMed
    1. Intersalt Cooperative Research Group . Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. BMJ. 1988;297:319–328. - PMC - PubMed
    1. He J, Ogden LG, Vupputuri S, et al. Dietary sodium intake and subsequent risk of cardiovascular disease in overweight adults. JAMA. 1999;282:2027–2034. - PubMed
    1. Tuomilehto J, Jousilahti P, Rastenyte D, et al. Urinary sodium excretion and cardiovascular mortality in Finland: a prospective study. Lancet. 2001;357:848–851. - PubMed
    1. Sacks FM, Svetkey LP, Vollmer WM, et al. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH‐Sodium Collaborative Research Group. N Engl J Med. 2001;344:3–10. - PubMed

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