MicroRNA as potential biomarkers in Glioblastoma

Zammam Areeb¹, Stanley S Stylli^{1

2}, Rachel Koldej^{3

4

5}, David S Ritchie^{3

4

5}, Tali Siegal⁶, Andrew P Morokoff^{1

2}, Andrew H Kaye^{1

2}, Rodney B Luwor⁷

Affiliations

¹ Clinical Sciences Building, Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia.
² Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia.
³ ACRF Translational Research Laboratory, Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia.
⁴ Haematology and Immunology Translational Research Laboratory, Cancer Immunology Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
⁵ Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
⁶ Center for Neuro-Oncology, Davidoff Institute of Oncology, Rabin Medical Center, Petach Tokva, Israel.
⁷ Clinical Sciences Building, Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia. rluwor@unimelb.edu.au.

PMID: 26391593
DOI: 10.1007/s11060-015-1912-0

Review

MicroRNA as potential biomarkers in Glioblastoma

Zammam Areeb et al. J Neurooncol. 2015 Nov.

. 2015 Nov;125(2):237-48.

doi: 10.1007/s11060-015-1912-0. Epub 2015 Sep 21.

Authors

Zammam Areeb¹, Stanley S Stylli^{1

2}, Rachel Koldej^{3

4

5}, David S Ritchie^{3

4

5}, Tali Siegal⁶, Andrew P Morokoff^{1

2}, Andrew H Kaye^{1

2}, Rodney B Luwor⁷

Affiliations

¹ Clinical Sciences Building, Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia.
² Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia.
³ ACRF Translational Research Laboratory, Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia.
⁴ Haematology and Immunology Translational Research Laboratory, Cancer Immunology Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
⁵ Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
⁶ Center for Neuro-Oncology, Davidoff Institute of Oncology, Rabin Medical Center, Petach Tokva, Israel.
⁷ Clinical Sciences Building, Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia. rluwor@unimelb.edu.au.

PMID: 26391593
DOI: 10.1007/s11060-015-1912-0

Abstract

Glioblastoma is the most aggressive and lethal tumour of the central nervous system and as such the identification of reliable prognostic and predictive biomarkers for patient survival and tumour recurrence is paramount. MicroRNA detection has rapidly emerged as potential biomarkers, in patients with glioblastoma. Over the last decade, analysis of miRNA in laboratory based studies have yielded several candidates as potential biomarkers however, the accepted use of these candidates in the clinic is yet to be validated. Here we will examine the use of miRNA signatures to improve glioblastoma stratification into subgroups and summarise recent advances made in miRNA examination as potential biomarkers for glioblastoma progression and recurrence.

Keywords: Biomarker; Glioblastoma; MicroRNA.

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References

1. J Clin Neurosci. 2015 Mar;22(3):570-4 - PubMed
1. J Clin Neurosci. 2013 Jul;20(7):933-7 - PubMed
1. Neuro Oncol. 2010 Jan;12(1):49-57 - PubMed
1. Lancet Oncol. 2009 May;10 (5):459-66 - PubMed
1. J Clin Neurosci. 2012 Mar;19(3):436-42 - PubMed

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MicroRNA as potential biomarkers in Glioblastoma

Affiliations

MicroRNA as potential biomarkers in Glioblastoma

Authors

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Abstract

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Medical