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Comment
. 2015 Sep 21;212(10):1482.
doi: 10.1084/jem.21210insight1.

Major progress in understanding progression in chronic myeloid leukemia

Jerry Radich  1
Affiliations
Comment

Major progress in understanding progression in chronic myeloid leukemia

Jerry Radich. J Exp Med. .
No abstract available

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Figures

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Insight from Jerry Radich
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A highly simplified model of CML progression. A genotoxic insult (lightening bolt) cases the BCR-ABL translocation. BCR-ABL induces myeloid proliferation and also results in genomic instability. Without therapy, unopposed BCR-ABL signaling causes new chromosomal changes, mutations, and changes in gene expression, causing a block in differentiation, further increases in cell cycling, and decreased apoptosis. In the figure, *** indicates the genetic changes in addition to BCR-ABL that promote progression to advanced phase CML (accelerated and blast phases). The “index of progression” is an artificial construct suggesting the cumulative affect of many changes in gene structure and function.
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References

    1. Giotopoulos, G., et al. . 2015. J. Exp. Med. 10.1084/jem.20141661 - DOI - PubMed

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