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Comment
. 2015 Sep 21;212(10):1484.
doi: 10.1084/jem.21210insight3.

Getting close to the action elicits better memories

Jason G Cyster  1
Affiliations
Comment

Getting close to the action elicits better memories

Jason G Cyster. J Exp Med. .
No abstract available

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Insight from Jason Cyster
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Anatomical differences that may contribute to induction of influenza strain cross-reactive B cells in the lung. The diagram on left shows paths of antigen (Ag) travel and sites of GC formation (iBALT, induced bronchial-associated lymphoid tissue, appears about 1 week after infection), which differ in the generation of HA-binding, cross-reactive GC B cells (green) at day 30 after intranasal infection with influenza A virus X31. The table summarizes key differences between sites, including the timing of the peak GC response, amount and form of Ag remaining at day 30, Ig mutation load (Bmem mutations), and the presence of cross-reactive Bmem. Data on the peak GC response, Ig mutation load, and cross-reactive B cell frequencies are based on the findings reported in Adachi et al.
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References

    1. Adachi, Y., et al. . 2015. J. Exp. Med. 10.1084/jem.20142284 - DOI

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