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. 2016 Apr;18(4):329-36.
doi: 10.1111/jch.12670. Epub 2015 Sep 23.

Changes in Central Hemodynamics in Women With Hypertensive Pregnancy Between Before and After Delivery

Taishi Fukushima  1 , Kazuo Eguchi  1 , Akihide Ohkuchi  2 , Hiroshi Miyashita  1 , Kazuomi Kario  1
Affiliations

Changes in Central Hemodynamics in Women With Hypertensive Pregnancy Between Before and After Delivery

Taishi Fukushima et al. J Clin Hypertens (Greenwich). 2016 Apr.

Abstract

The authors tested the hypothesis that central hemodynamic parameters in women with hypertensive disorders of pregnancy (HDP) change between before and after delivery. A total of 137 pregnant women were studied: 72 with HDP, 42 with chronic hypertension (CH), and 23 with white-coat hypertension (WCH; control group). Aortic augmentation index adjusted by heart rate 75 beats per minute (AIx@75), central pulse pressure (PP), total peripheral resistance (TPR), and cardiac output (CO) before and after delivery were recorded. AIx@75 and central PP were higher in the HDP group than in the control group, but both parameters declined after delivery until they were similar to the controls. AIx@75 and central PP, but not TPR or CO, were significantly decreased after delivery in the HDP group, but no such effects were seen in the other groups. These findings suggest that increased wave reflection caused by the stiffened aorta could be a key factor in the pathophysiology of HDP.

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Figures

Figure 1
Figure 1
Central pulse pressure (PP) and augmentation index adjusted by heart rate 75 beats per minute (AIx@75) between before and after delivery. HDP indicates hypertensive disorders of pregnancy; CH, chronic hypertension. Error bars=standard errors.
Figure 2
Figure 2
Changes in total peripheral resistance and cardiac output between before and after delivery. HDP indicates hypertensive disorders of pregnancy; CH, chronic hypertension. Error bars=standard errors.
See this image and copyright information in PMC

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