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. 2015 Sep 15;142(18):3077-84.
doi: 10.1242/dev.126482.

The advancement of human pluripotent stem cell-derived therapies into the clinic

R Scott Thies  1 , Charles E Murry  2
Affiliations

The advancement of human pluripotent stem cell-derived therapies into the clinic

R Scott Thies et al. Development. .

Erratum in

Abstract

Human pluripotent stem cells (hPSCs) offer many potential applications for drug screening and 'disease in a dish' assay capabilities. However, a more ambitious goal is to develop cell therapeutics using hPSCs to generate and replace somatic cells that are lost as a result of disease or injury. This Spotlight article will describe the state of progress of some of the hPSC-derived therapeutics that offer the most promise for clinical use. Lessons from developmental biology have been instrumental in identifying signaling molecules that can guide these differentiation processes in vitro, and will be described in the context of these cell therapy programs.

Keywords: Clinical medicine; HPSC-cardiomyocytes; Human Pluripotent Stem Cell.

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Figures

Fig. 1.
Fig. 1.
hPSC-derived cell therapeutics advancing to clinical testing. hPSC-derived cell therapeutics advancing to clinical testing include retinal pigment epithelium (RPE) for retinal degenerative diseases, dopaminergic neurons (Neurons) for Parkinson's disease, cardiomyocytes for heart disease, oligodendrocyte progenitor cells (OPCs) for spinal cord injury and β-islet cells (β cells) for diabetes.
See this image and copyright information in PMC

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