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Clinical Trial
. 2015 Aug;159(4):576-81.
doi: 10.1007/s10517-015-3017-3. Epub 2015 Sep 22.

The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus

Yu N Rushkevich  1 , S M Kosmacheva  2 , G V Zabrodets  3 , S I Ignatenko  2 , N V Goncharova  2 , I N Severin  2 , S A Likhachev  3 , M P Potapnev  4
Affiliations
Clinical Trial

The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus

Yu N Rushkevich et al. Bull Exp Biol Med. 2015 Aug.

Abstract

We studied a new method of treatment of amyotrophic lateral sclerosis with autologous mesenchymal stem cells. Autologous mesenchymal stem cells were injected intravenously (intact cells) or via lumbar puncture (cells committed to neuronal differentiation). Evaluation of the results of cell therapy after 12-month follow-up revealed slowing down of the disease progression in 10 patients in comparison with the control group consisting of 15 patients. The cell therapy was safe for the patients.

Keywords: ALSFRS-R; Karnofsky scale; amyotrophic lateral sclerosis; autologous mesenchymal stem cells; neurogenic differentiation.

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