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. 2016 Jan 15;32(2):283-5.
doi: 10.1093/bioinformatics/btv546. Epub 2015 Sep 22.

Approximately independent linkage disequilibrium blocks in human populations

Tomaz Berisa  1 , Joseph K Pickrell  2
Affiliations

Approximately independent linkage disequilibrium blocks in human populations

Tomaz Berisa et al. Bioinformatics. .

Abstract

We present a method to identify approximately independent blocks of linkage disequilibrium in the human genome. These blocks enable automated analysis of multiple genome-wide association studies.

Availability and implementation: code: http://bitbucket.org/nygcresearch/ldetect; data: http://bitbucket.org/nygcresearch/ldetect-data.

Contact: tberisa@nygenome.org

Supplementary information: Supplementary data are available at Bioinformatics online.

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Figures

Fig. 1.
Fig. 1.
(a) and (b) Schematic of the conversion of matrix P to vector V. (c) Example data (blue) with Hann filter applied (red). (d) Example of Crohn’s disease GWAS hits with partially filtered vector V and comparison of breakpoints
See this image and copyright information in PMC

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