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. 2011 Summer;9(3):203-8.

Successful pregnancy following the transfer of vitrified blastocyst which developed from poor quality embryos on day 3

Xiao-Jian Zhang  1 , Ye-Zhou Yang  1 , Li-Hua Min  1 , Qun Lv  1 , Pin Bai  1 , Xiao-Jie Li  1 , Mei-Xu Liao  1
Affiliations

Successful pregnancy following the transfer of vitrified blastocyst which developed from poor quality embryos on day 3

Xiao-Jian Zhang et al. Iran J Reprod Med. 2011 Summer.

Abstract

Background: The selection of pre-embryos for transferred is based on morphological appearance. But some poor quality cleaved embryos also can be cultured to the blastocyst stage and implanted.

Objective: To assess the clinical pregnancy outcomes of blastocyst transfer which developed from poor quality embryos.

Materials and methods: A total of 109 cleaved embryos with poor quality were cultured to day 5/day 6 and 27 (24.8%) blastocysts were collected from the 15 cycles/patients undergoing conventional IVF. All the blastocysts were cooling with fast-freezing. Then the blastocysts were warmed for transfer.

Results: All of 25 vitrified blastocysts (92.6%) survived after warming and were transferred to 15 patients. Five of the women became pregnant.

Conclusion: Our results suggest that vitrified human day 5/day 6 blastocyst transfer which develop from poor quality embryo at day 3 can contribute to increasing cumulative pregnancy rates in assisted reproduction.

Keywords: Poor quality embryos; Pregnancy; Vitified Blastocyst- transfer.

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References

    1. Farhi J, Nahum H, Weissman A, Roybur M, Glezerman M, Levran D. The value of culturing to the blastocyst stage of supernumerary embryos not suitable for freezing after embryo transfer at day 3. Fertil Steril. 2001;76 (Suppl.):118.
    1. Hardarson T, Hanson C, Sjögren A, Lundin K. Human embryos with unevenly sized blastomeres have lower pregnancy and implantation rates: indications for aneuploidy and multinucleation. Hum Reprod. 2001;16:313–318. - PubMed
    1. Rijnders PM, Jansen CA. The predictive value of day 3 embryo morphology regarding blastocyst formation, pregnancy and implantation rate after day 5 transfer following in-vitro fertilization or intracytoplasmic sperm injection. Hum Reprod. 1998;13:2869–2873. - PubMed
    1. Balaban B, Urman B, Alatas C, Mercan R, Aksoy S, Isiklar A. Blastocyst-stage transfer of poor-quality cleavage-stage embryos results in higher implantation rates. Fertil Steril. 2001;75:514–518. - PubMed
    1. Hiraoka K, Hiraoka K, Kinutani M, Kinutani K. Vitrification of human hatched blastocysts: a report of 4 cases. J Reprod Med. 2007;52:413–415. - PubMed

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