Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2015 Sep 24:5:14483.
doi: 10.1038/srep14483.

Noninvasive Ventilation for Preterm Twin Neonates with Respiratory Distress Syndrome: A Randomized Controlled Trial

Long Chen  1 , Li Wang  1 , Jie Li  2 , Nan Wang  1 , Yuan Shi  1
Affiliations
Randomized Controlled Trial

Noninvasive Ventilation for Preterm Twin Neonates with Respiratory Distress Syndrome: A Randomized Controlled Trial

Long Chen et al. Sci Rep. .

Abstract

Noninvasive ventilation has been proven to be effective strategies for reducing the need for endotracheal ventilation in preterm infant with respiratory distress syndrome (RDS), however the best option needs to be further determined. A single center, paired design, randomized, controlled trial was conducted between Jan 2011 and July 2014. Preterm twins with RDS were included. One of a pair was randomized to NIPPV, while another to NCPAP. Surfactant was administrated as rescue treatment. The primary outcome was the need for endotracheal ventilation. The secondary outcomes were the complications. 143 pairs were randomized and 129 pairs finished the trial. The rates of endotracheal ventilation did not differ significantly between NIPPV and NCPAP groups (11.9% vs 19.6%, P = 0.080). This difference was not observed in the subgroup of infants who received surfactant therapy (11.1% vs 19.7%, P = 0.087). No secondary outcomes also differed significantly between the two groups. NIPPV did not result in a significantly lower incidence of intubation as compared with NCPAP in preterm twins with RDS.

PubMed Disclaimer

Figures

Figure 1
Figure 1. The flow diagram.
See this image and copyright information in PMC

References

    1. Caryn S. C. et al. The probability of neonatal respiratory distress syndrome as a function of gestational age and lecithin/sphingomyelin ratio. Am J Perinatol. 25, 473–480 (2008). - PMC - PubMed
    1. Stoll B. J. et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 126, 443–456 (2010). - PMC - PubMed
    1. Schmidt B. et al. Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birthweight infants at 18 months: results from the Trial of Indomethacin Prophylaxis in Preterms. JAMA. 289, 1124–1129 (2010). - PubMed
    1. Stroustrup A. & Trasande L. Epidemiological characteristics and resource use in neonates with bronchopulmonary dysplasia: 1993–2006. Pediatrics. 126, 291–297 (2010). - PubMed
    1. Long C., Jie L., Nan W. & Yuan S. Post-Newborn: A New Concept of Period in Early Life. Frontier and Future Development of Information Technology in Medicine and Education. LNEE. 269, 1343–1350 (2014).

Publication types