Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Dec;53(12):3947-50.
doi: 10.1128/JCM.01762-15.

Francisella philomiragia Bacteremia in a Patient with Acute Respiratory Insufficiency and Acute-on-Chronic Kidney Disease

Ryan F Relich, Romney M Humphries, H Reid Mattison, Jessica E Miles, Edward R Simpson, Ian J Corbett, Bryan H Schmitt, M May
Case Reports

Francisella philomiragia Bacteremia in a Patient with Acute Respiratory Insufficiency and Acute-on-Chronic Kidney Disease

Ryan F Relich et al. J Clin Microbiol. 2015 Dec.

Abstract

Francisella philomiragia is a very uncommon pathogen of humans. Diseases caused by it are protean and have been reported largely in near-drowning victims and those with chronic granulomatous disease. We present a case of F. philomiragia pneumonia with peripheral edema and bacteremia in a renal transplant patient and review the diverse reports of F. philomiragia infections.

PubMed Disclaimer

Figures

FIG 1
FIG 1
Imaging and phylogeny of F. philomiragia isolate 14IUHPL001. (A) Gram-stained smear of positive blood culture bottle demonstrating small, pleomorphic Gram-negative coccobacilli (bar, 10 μm). Neighbor-joining trees were generated based on 16S rRNA gene sequence or concatemers of MLST targets. (B) A tree generated using 16S rRNA gene input sequence from all Francisella species (outgroup = Piscirickettsia salmonis) indicates that isolate 14IUHPL001 (arrow) groups with the type strain (FSC 144T) of F. philomiragia subspecies philomiragia, indicating a species identification of F. philomiragia. (C) A second tree generated using a concatemerized sequence of MLST targets from 6 strains of F. philomiragia subsp. philomiragia and a single strain of F. noatunensis (outgroup = F. tularensis subsp. tularensis) indicates that isolate 14IUHPL001 (arrow) branches closely with the type strain FSC144T and is appropriately identified as F. philomiragia subsp. philomiragia at the subspecies level.
See this image and copyright information in PMC

References

    1. Weisburg WG, Barns SM, Pelletier DA, Land DJ. 1991. 16S ribosomal DNA amplification for phylogenetic study. J Bacteriol 173:697–703. - PMC - PubMed
    1. Benson DA, Clark K, Karsch-Mizrachi I, Lipman DJ, Ostell J, Sayers EW. 2015. GenBank. Nucleic Acids Res 43(Database issue):D30–D35. - PMC - PubMed
    1. Sievers F, Higgins DG. 2014. Clustal Omega, accurate alignment of very large numbers of sequences. Methods Mol Biol 1079:105–116. doi:10.1007/978-1-62703-646-7_6. - DOI - PubMed
    1. Letunic I, Bork P. 2011. Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy. Nucleic Acids Res 39(Web Server issue):W475–W478. - PMC - PubMed
    1. Seibold E, Maier T, Kostrzewa M, Zeman E, Splettstoesser W. 2010. Identification of Francisella philomiragia by whole-cell matrix-assisted laser desorption ionization-time of flight mass spectrometry: fast, reliable, robust, and cost-effective differentiation on species and subspecies levels. J Clin Microbiol 48:1061–1069. doi:10.1128/JCM.01953-09. - DOI - PMC - PubMed

Publication types

MeSH terms