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Review
. 2015 Apr-Jun;4(2):187-91.
doi: 10.5455/jice.20150402062823. Epub 2015 Apr 3.

Caffeic acid phenethyl ester as a remedial agent for reproductive functions and oxidative stress-based pathologies of gonads

Sumeyya Akyol  1 , Ali Akbas  2 , Ilknur Butun  2 , Muhsin Toktas  3 , Huseyin Ozyurt  2 , Semsettin Sahin  2 , Omer Akyol  4
Affiliations
Review

Caffeic acid phenethyl ester as a remedial agent for reproductive functions and oxidative stress-based pathologies of gonads

Sumeyya Akyol et al. J Intercult Ethnopharmacol. 2015 Apr-Jun.

Abstract

In recent years, the studies on the roles of caffeic acid phenethyl ester (CAPE) in several disease models and cell cultures are tremendously growing. It is such a great molecule that was used by ancient times to ameliorate some diseases and nowadays, it is used by modern medicine to test the effectiveness. In this mini-review article, the protection capability of CAPE, as a liposoluble antioxidant and a potent nuclear factor kappa B inhibitor, on oxidative and non-oxidative ovary, and testis damages has been summarized. In view of our laboratory findings/experience and those reported in the hitherto literature, we suggest that CAPE possesses protective effects for pathologies of the reproductive organs induced by untoward effects of harmful molecules such as free oxygen radicals, pesticides, methotrexate, and MK-801 (dizocilpine).

Keywords: Caffeic acid phenethyl ester; gonads; ovary; oxidative damage; protection; testis.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
The chemical structure of caffeic acid phenethyl ester
Figure 2
Figure 2
Proposed mechanism for the relationship between oxidative stress and the protective effect of caffeic acid phenethyl ester on reproductive organs
See this image and copyright information in PMC

References

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