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. 2015;48(3):863-9.
doi: 10.3233/JAD-150018.

Neuropsychiatric Symptoms Predict Functional Status in Alzheimer's Disease

S Christine You  1 , Christine M Walsh  2 , Louis A Chiodo  3 , Robin Ketelle  2 , Bruce L Miller  2 , Joel H Kramer  2
Affiliations

Neuropsychiatric Symptoms Predict Functional Status in Alzheimer's Disease

S Christine You et al. J Alzheimers Dis. 2015.

Abstract

Background: Cognitive deficits are presumed to be the primary driver of functional impairment in Alzheimer's disease (AD); however, functional impairment is likely multifactorially determined.

Objective: Our objective was to determine the relative contribution of neuropsychiatric symptoms in predicting ratings of functional status.

Methods: A total of 223 patients received routine neurological and neuropsychological evaluations and met criteria of probable AD dementia based on the McKhann criteria. Demographic, cognitive, and neuropsychiatric variables were entered in a hierarchical linear regression analysis to predict functional status as measured by the Functional Activities Questionnaire (FAQ).

Results: The total model explained 29.7% of the variance (p < 0.001) in FAQ. Importantly, neuropsychiatric variables explained 12.7% of the unique variance, with apathy and sleep as significant contributors.

Conclusion: Two neuropsychiatric variables, apathy and changes in sleep/nighttime behaviors, predicted ratings of functional status in AD patients independent of age, global cognition, memory and executive function measures, and depressive symptoms. These results highlight the importance of neuropsychiatric symptoms in understanding and potentially treating the functional limitations so prevalent in AD.

Keywords: Alzheimer’s disease; apathy; neuropsychology; sleep disorders.

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References

    1. Prince M, Bryace R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: A systematic review and metaanalysis. Alzheimers Dement. 2013;9:63–75. - PubMed
    1. Benke T, Delazer M, Sanin G, Schmidt H, Seiler S, Ransmayr G, Dal-Bianco P, Uranüs M, Marksteiner J, Leblhuber F, Kapeller P, Bancher C, Schmidt R. Cognition, gender, and functional abilities in Alzheimer’s disease: How are they related? J Alzheimers Dis. 2013;35:247–252. - PubMed
    1. Boyle PA, Malloy PF, Salloway S, Cahn-Weiner DA, Cohen R, Cummings JL. Executive dysfunction and apathy predict functional impairment in Alzheimer disease. AmJ Geriatr Psychiatry. 2003;11:214–221. - PubMed
    1. Cahn-Weiner DA, Malloy PF, Boyle PA, Marran M, Salloway S. Prediction of functional status from neuropsychological tests in community-dwelling elderly individuals. Clin Neuropsychol. 2000;14:187–195. - PubMed
    1. Farias ST, Harrell E, Neumann C, Houtz A. The relationship between neuropsychological performance and daily functioning in individuals with Alzheimer’s disease: Ecological validity of neuropsychological tests. Arch Clin Neuropsychol. 2003;18:655–672. - PubMed

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