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Editorial
. 2015;15(10):1123-5.
doi: 10.1586/14737140.2015.1086648. Epub 2015 Sep 7.

Vasectomy: potential links to an increased risk of aggressive prostate cancer?

Alexis R Gaines  1   2 , Adriana C Vidal  1   2 , Stephen J Freedland  1   3   2   4
Affiliations
Editorial

Vasectomy: potential links to an increased risk of aggressive prostate cancer?

Alexis R Gaines et al. Expert Rev Anticancer Ther. 2015.

Abstract

Several studies have found associations between aggressive prostate cancer (PC) and having a vasectomy. However, findings from two very recent meta-analyses have found that this is not the case. Therefore, the data are mixed. Herein, we detail the controversy between vasectomy and PC risk, particularly aggressive PC, by shedding some light on the molecular pathways, potential risk factors and suggested links for those considering vasectomy and medical professionals who perform it. We conclude by supporting the American Urological Association's position that there is no need to discuss potential prostate cancer risks with patients considering vasectomy given reasonably strong data finding no link between vasectomy and prostate cancer risk.

Keywords: cancer; epidemiology; prostate; risk; vasectomy.

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Conflict of interest statement

competing interests disclosure

The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

References

    1. Sharlip ID, Belker AM, Honig S, et al. Vasectomy: AUA guideline. The Journal of urology. 2012;188(6 Suppl):2482–2491. - PubMed
    1. Rohrmann S, Paltoo DN, Platz EA, Hoffman SC, Comstock GW, Helzlsouer KJ. Association of vasectomy and prostate cancer among men in a Maryland cohort. Cancer causes & control: CCC. 2005;16(10):1189–1194. - PubMed
    1. Giovannucci E, Tosteson TD, Speizer FE, Ascherio A, Vessey MP, Colditz GA. A retrospective cohort study of vasectomy and prostate cancer in US men. Jama. 1993;269(7):878–882. - PubMed
    1. Siddiqui MM, Wilson KM, Epstein MM, et al. Vasectomy and risk of aggressive prostate cancer: a 24-year follow-up study. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2014;32(27):3033–3038. - PMC - PubMed
    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA: a cancer journal for clinicians. 2015;65(1):5–29. - PubMed

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