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. 2015 Dec 15;61(12):1831-4.
doi: 10.1093/cid/civ720. Epub 2015 Sep 24.

Patterns of Hydrocephalus Caused by Congenital Toxoplasma gondii Infection Associate With Parasite Genetics

Samuel L Hutson  1 , Kelsey M Wheeler  1 , David McLone  2 , David Frim  3 , Richard Penn  4 , Charles N Swisher  2 , Peter T Heydemann  5 , Kenneth M Boyer  5 , A Gwendolyn Noble  2 , Peter Rabiah  6 , Shawn Withers  1 , Jose G Montoya  7 , Kristen Wroblewski  8 , Theodore Karrison  8 , Michael E Grigg  9 , Rima McLeod  1
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Patterns of Hydrocephalus Caused by Congenital Toxoplasma gondii Infection Associate With Parasite Genetics

Samuel L Hutson et al. Clin Infect Dis. .

Abstract

Four anatomical patterns of hydrocephalus secondary to congenital Toxoplasma gondii infection were identified and characterized for infants enrolled in the National Collaborative Chicago-based Congenital Toxoplasmosis Study. Analysis of parasite serotype revealed that different anatomical patterns associate with Type-II vs Not-Exclusively Type-II strains (NE-II) (P = .035).

Keywords: Toxoplasma gondii; aqueductal obstruction; foraminal obstruction; hydrocephalus.

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Figures

Figure 1.
Figure 1.
Anatomical patterns of hydrocephalus in congenital Toxoplasma gondii infection and association with parasite strain. The large dark areas in the neuroimages indicate the dilated ventricular regions and hydrocephalus. A, Obstruction of the aqueduct of Sylvius; aqueduct of Sylvius indicated by blue arrow. B1, Bilateral obstruction of the foramina of Monro; foramina of Monro indicated by red arrow. B2, Unilateral obstruction of the foramina of Monro. C, No obvious intraventricular obstruction causing ventricular dilatation. D, Twenty-four patients had antibodies to Type-II peptides, and 33 had antibodies to NE-II peptides. Type-II strains were associated with aqueductal obstruction and NE-II strains were associated with nonobstructive hydrocephalus (P = .035). % Total = (Number of patients with antibodies to parasite strain and pattern of hydrocephalus/Total number of patients with antibodies to parasite strain) × 100.
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