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. 2015 Mar;50(3):214-20.
doi: 10.1310/hpj5003-214.

Compatibility of Cloxacillin Sodium with Selected Intravenous Drugs During Simulated Y-Site Administration

Thomas Sullivan  1 , Jean-Marc Forest  2 , Grégoire Leclair  3
Affiliations

Compatibility of Cloxacillin Sodium with Selected Intravenous Drugs During Simulated Y-Site Administration

Thomas Sullivan et al. Hosp Pharm. 2015 Mar.

Abstract

Background: Data regarding Y-site compatibility of intravenous (IV) cloxacillin sodium with other drugs are scarce and incomplete.

Objective: To establish the compatibility of IV cloxacillin with 89 injectable drugs during simulated Y-site administration.

Methods: Cloxacillin sodium (10 mL, 100 mg/mL) was combined with 89 undiluted IV drugs (10 mL, each). Tests were duplicated and performed at room temperature. Visual evaluation and a light obscuration particle count test were performed on 1 of the 2 solutions immediately after mixing. The second mixture underwent visual evaluation after 15 minutes, 1 hour, and 4 hours, followed by a particle count test at 4 hours. Drugs were considered incompatible if the mixture precipitated or became turbid within the 4-hour period or exceeded the particle count limit allowed by Test 1.B of USP <788> initially or at 4 hours.

Results: Of the 89 tested drugs, 64 were compatible for up to 4 hours. The remaining 25 drugs were incompatible. Of these incompatible drugs, 16 were identified visually, and 9 were identified by the light obscuration particle count test.

Conclusions: Sixty-four IV drugs were found to be compatible with cloxacillin via simulated Y-site, whereas 25 drugs were found to be incompatible with the antibiotic. The light obscuration particle count test should be used to complement visual evaluation when samples do not precipitate immediately.

Keywords: Y-site; cloxacillin; compatibility.

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