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. 2015 Oct;65(5):328-34.
doi: 10.1007/s13224-014-0614-4. Epub 2014 Nov 1.

Histomorphological Patterns of Endometrium in Infertility

Shirish S Nandedkar  1 , Ekta Patidar  1 , Dhiraj B Gada  2 , Kamal Malukani  1 , Kavita Munjal  1 , Amit Varma  1
Affiliations

Histomorphological Patterns of Endometrium in Infertility

Shirish S Nandedkar et al. J Obstet Gynaecol India. 2015 Oct.

Abstract

Background: Endometrium is the most sensitive indicator of ovarian function and endometrial biopsy is one of the most important investigations in infertility. The current study was carried out to investigate the histomorphological patterns of endometrium in infertile women and to compare the results with other similar studies.

Materials and methods: A cross-sectional study on 2,080 infertile women was carried out to find the incidence of various histomorphological patterns in hematoxylin-eosin stained sections of endometrium and compare them with other Indian studies.

Results: In the current study majority of cases (88.50 %) were of primary infertility; the highest number of cases was in the age group of 21-30 years and the oldest patient was of 50 years age. The various abnormalities observed were anovulatory endometrium (15.75 %), inadequate proliferative (1.90 %), inadequate secretory (9.52 %), glandulo-stromal disparity (GSD) (4.21 %), hyperplasia (1.10 %), and endometritis (1.63 %). In 3.0 % cases menstrual cycle history was not available and curettage was done at inappropriate period of the cycle in 11.63 %. Comparison with other studies revealed the results matching with some and differing with others.

Conclusion: In the current study, anovulatory endometrium and luteal phase defect are the major causes of infertility, and tuberculous endometritis, non-specific endometritis and GSD are minor contributing factors. These are treatable causes. Premenstrual endometrial biopsy, if accompanied by information of menstrual cycle and date of biopsy, can be a very reliable diagnostic tool for hormonal dysfunction and intrinsic endometrial factors in infertility.

Keywords: Endometrium; Glandulo-stromal disparity; Histomorphological patterns; Infertility; Luteal phase; Sterility.

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References

    1. Okonofua FE. The social meaning of infertility in south-west Nigeria. Health Transit Rev. 1997;7:205–220.
    1. Zegers-Hochschild F, Adamson GD, de Mouzon J, et al. The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology 2009. Human Reprod. 2009;24:2683–2687. doi: 10.1093/humrep/dep343. - DOI - PubMed
    1. Kleegman SJ, Kaufmann SA. Infertility in women. 1st ed. Philadelphia: FA Davis Company Publishers; 1966.
    1. Hall JE. Infertility and fertility control. In: Adams D, editor. Harrison’s principles of internal medicine, vol 1. 16th ed. New York: McGraw Hill Medical Publishing Division; 2005. p. 279–80.
    1. District Level Household and Facility Survey 3 (DLHS-3), 2007–2008. India; 170. www.rchiips.org/pdf/INDIA_REPORT_DLHS-3.

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